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Introduction: Human life expectancy has increased significantly, leading to a transformation in the global demographic structure. Cancer is considerably more common among older adults compared to younger populations, as age is one of the main risk factors for its development. In fact, most solid tumors are considered age-related diseases. For this reason, the incidence of cancer among older individuals is expected to continue rising. Oncological care for this population group is particularly complex and represents a significant challenge, as comorbidities and the social aspects of aging create clinical scenarios that differ greatly from those seen in younger patients.
Objective: To identify the predictive factors of functional decline and quality of life at 12 months of follow-up, as well as oncological outcomes at 5 years of follow-up, in patients aged 65 years and older with gastrointestinal cancer who undergo curative-intent resective surgery at Hospital Universitario Mayor - Méderi, Bogotá, Colombia.
Methodology: Longitudinal and analytical observational study of prospective prognostic cohort type.
Expected Results: Predictive model of functional decline and quality of life, as well as oncological outcomes, in patients with gastrointestinal cancer undergoing curative-intent surgical procedures.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients aged over 65 years with a gastrointestinal tract cancer diagnosis | Patients aged over 65 years with a gastrointestinal tract cancer diagnosis that are taken to surgery with a curative intent. |
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| Measure | Description | Time Frame |
|---|---|---|
| Predictive factors associated with functional and quality of life decline at 12 months | Factors associated with functional and quality of life decline at 12 months follow-up | 12 months |
| Predictive factors associated with oncological outcomes | Predictive factors associated with oncological outcomes | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Population characterization | To describe demographical, clinical, paraclinical, presurgical functional and of quality of life, and surgical outcomes in patients ≥65 years of age with a gastrointestinal tract cancer diagnosis taken to surgery with a curative intent | 5 years |
| Surgical and functional outcomes |
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Inclusion Criteria:
Exclusion Criteria:
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Patients ≥65 years of age with a gastrointestinal tract cancer diagnosis taken to surgery with a curative intent in the Hospital Universitario Mayor - Méderi, Bogotá, Colombia.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Camilo Ramírez-Giraldo, Surgeon | Contact | 3206770474 | ramirezgiraldocamilo@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Universitario Mayor-Méderi | Recruiting | Bogotá | Colombia |
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To describe postoperative surgical (mortality and complicactions) and functional and of quality of life outcomes at 1, 6, and 12 months followup in patients ≥65 years of age with a gastrointestinal tract cancer diagnosis taken to surgery with a curative intent |
| 1 year |
| Oncological outcomes | To describe oncological outcomes (overall survival, disease-free period, disease-specific survival) in patients ≥65 years of age with a gastrointestinal tract cancer diagnosis taken to surgery with a curative intent at 1, 3 and 5 years follow-up | 5 years |
| Comparison | To compare demographical, clinical, surgical, functional and of quality of life, and surgical outcomes in patients ≥65 years of age with a gastrointestinal tract cancer diagnosis taken to surgery with a curative intent that had functional and quality of life decline versus those that did not at 1, 6 and 12 months follow-up | 1 year |
| Qualitative evaluation | To evaluate predictive demographical, clinical, paraclinical factorsfor functional and of quality of life, and surgical for in patients ≥65 years of age with a gastrointestinal tract cancer diagnosis taken to surgery with a curative intent at 1, 6 and 12 months follow-up | 1 year |
| Oncological evaluation | To evaluate predictive demographical, clinical, paraclinical, presurgical, functional and of quality of life, and surgical factors for overall survival, disease-free period and disease-free survival in patients ≥65 years of age with a gastrointestinal tract cancer diagnosis taken to surgery with a curative intent at 1, 3 and 5 years follow-up | 5 years |
| Subgroup analysis | To explore functional and quality of life decline at 1, 6 and 12 months follow-up by subgroups according to decade groups. | 1 year |
| Internal validation | To perform an internal validation of a predictive model for functional and quality of life decline at 12 months follow-up in patients ≥65 years of age with a gastrointestinal tract cancer diagnosis taken to surgery with a curative intent | 1 year |