The goal of this clinical trial is to evaluate if transcranial direct current stimulation (tDCS) works to reduce occupational stress and burnout in university professors. The main questions it aims to answer are:

Does tDCS reduce levels of occupational stress in university professors?

Does tDCS reduce burnout levels in university professors?

Researchers will compare active tDCS to a sham stimulation (a look-alike procedure that contains no active stimulation) and a control group to see if tDCS effectively reduces stress and burnout.

Participants will:

• Complete questionnaires assessing stress and burnout levels before the intervention
• Complete follow-up assessments immediately after the intervention and 5 weeks later

During intervention, participans of active tDCS and Sham gruops will:

• Receive 10 sessions of tDCS over 4 weeks (excluding weekends), 20 minutes each

Occupational stress, defined as stress in the workplace context, is recognized as one of the main health problems in the work environment. Although having a profession is fundamental for financial support, professional fulfillment and social recognition, factors such as excessive pressure, workload overload and inadequate organizational environment can compromise workers' well-being, making it essential to seek a balance between productivity and health.

Occupational stress has been associated with reduced overall well-being, compromising essential cognitive functions such as concentration and work productivity. Professionals from various areas deal with this problem, particularly those who work directly with people and provide essential services, such as doctors, police officers, firefighters and university professors, being more susceptible to stress.

According to recent studies, university teaching activity has become increasingly demanding, reflected in high levels of work stress. Performance demands, pressure for scientific productivity, overload of administrative and teaching tasks, as well as contractual instability, are factors that contribute to a highly exhausting work environment. These pressures are not just individual perceptions but result from structural conditions present in higher education institutions, with significant impacts on teachers' health, well-being and quality of life.

When occupational stress is not effectively managed, it can become chronic and result in burnout, a disabling condition characterized by a sensation of physical and mental exhaustion, emotional distancing from work accompanied by a negative and cynical attitude towards professional activities, and a reduction in effectiveness and performance in the work environment. In university professors, burnout can reach alarming percentages. Studies reveal that among participants, a significant percentage present critical levels of burnout, requiring immediate intervention. In the national context, although identified burnout levels may not be particularly high, the reduced sample size and unequal distribution of analytical categories may have introduced biases that compromise the robustness of results. Therefore, it becomes evident the need to develop new investigations with larger and more representative samples, as well as using more advanced statistical methods, in order to deepen understanding of burnout in higher education professors and provide more solid bases for creating effective prevention and intervention strategies.

To deal with these problems, various strategies are recommended with relaxation techniques, such as yoga, which have proven effective in reducing occupational stress, especially among health professionals. Mindfulness-based approaches also play an important role in reducing stress and burnout, being widely applied to promote well-being at work. Additionally, music therapy has proven to be an effective complementary strategy in reducing stress, and can be applied in various professions to alleviate negative emotions. Beyond these approaches, new approaches such as non-invasive neuromodulation have shown promise.

Neuromodulation is a growing area that involves various specificities and has a significant impact on hundreds of patients and numerous diseases worldwide. Neuromodulation is a process that aims to modulate cortical excitability and promote synaptic plasticity in regions associated with executive control and the reward system.

Transcranial Direct Current Stimulation (tDCS) is a non-invasive neuromodulation technique that involves applying a continuous low-intensity electrical current directly to the scalp, focusing on the Prefrontal Cortex. It uses conductive materials, sponges and saline solutions to optimize current distribution, and its effects can persist for up to two hours after the session, depending on various factors such as polarity, intensity, duration and personal anatomy.

tDCS alters neuronal activity and promotes brain plasticity, that is, the brain's capacity to reorganize itself and acquire new knowledge. It is a safe approach, without serious or intolerable side effects, which has demonstrated efficacy in various conditions, such as Obsessive-Compulsive Disorder, Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder, Post-Traumatic Stress Disorder, and Major Depressive Disorder. However, even being a safe technique, tDCS can cause mild and temporary side effects, such as tingling at the electrode site, slight headache, burning sensation on the skin.

Regarding studies with stress and burnout, research suggests that tDCS also plays a significant role in reducing stress and consequently burnout, contributing to an improvement in professional performance and well-being in the work environment. Nevertheless, there is a need for more studies, especially in the context of university teaching, where research remains quite limited. Even after searching various academic databases, no specific articles were found on the use of tDCS in university professors.

Given the need to explore innovative approaches that contribute to mitigating the negative impacts and high occupational stress and burnout in this population, and the potential of tDCS, this dissertation proposes to investigate the effects of neuromodulation as a possible response. The central hypothesis to be tested is: "Neuromodulation will have a significant impact on reducing occupational stress and burnout in Higher Education."

The intervention will consist of ten tDCS sessions, distributed over four weeks (excluding Saturday and Sunday), lasting 20 minutes each. There will be no less than 24 hours between sessions for safety reasons, nor more than 72 hours between sessions to minimize loss of the cumulative effect of tDCS. The intensity of the applied current will be 1.2 mA, with the anode electrode positioned over the left prefrontal cortex (F3 position) and the cathode electrode over the right prefrontal cortex (F4 position). After the intervention, participants complete the post-intervention protocol, which is repeated five weeks later (follow-up). There will also be a control group that will only complete all protocols, without any intervention, with a view to identifying a potential effect of environmental variables on the results.

Inclusion Criteria:

• University staff in active functions
• Age equal to or greater than 18 years
• Availability for the 10 intervention sessions and subsequent assessments
• Voluntary participation with informed consent

Exclusion Criteria:

• Contraindications for tDCS, namely pregnancy, history of seizures or epilepsy, neurological or anatomical contraindications, metal implants or brain surgeries
• Initiation or change in prescription of psychotropic drugs or anticonvulsants in the last 3 months
• Recent active psychotherapy
• Diagnosis of psychiatric condition in the last year

Individual participant data (IPD) will not be shared because the informed consent obtained for this study did not include permission to share de-identified participant-level data with external researchers. If an ethics/IRB amendment and participant authorization (e.g., re-consent) are obtained in the future, the study team may update this record and make a de-identified dataset available under controlled access.

The PlatoScience company will remotely configure user accounts as either experimental or sham condition without providing information about participants to the company. The research team will not have knowledge of which accounts are experimental and which are sham until the end of the study, ensuring double-blind conditions. The outcomes assessor role is also masked as assessments are conducted through self-report questionnaires administered identically across all groups.