Predicting Weight Loss After Pharmacological or Surgical Treatment in Patients With Obesity

Research of Predictive Factors of Weight Loss After Pharmacological or Surgical Treatment in Patients Suffering From Obesity

As with other nutritional strategies, the clinical response to bariatric surgery can be highly variable, with weight regain being a frequent occurrence. Recent evidence on anti-obesity medication indicate similar inter-individual variability in clinical response. Among multiples factors, co-occurrence of eating disorders such as binge eating disorder has been implicated in insufficient clinical response. Improving our ability to predict how patients will respond to obesity treatment is necessary in order to tailor the care pathways we offer. The mechanisms involved in disturbances of eating behaviour before and after surgery remain largely unknown. This study aims to identify the predictive factors of weight loss after pharmacological or surgical treatment, as well as the cognitive and biological mechanisms that mediate this effect.

Inclusion criteria:

• Age between 18 and 65 years
• Obesity, with bariatric surgery indicated after a multidisciplinary evaluation in case of surgical treatment.
• Good physical and mental health, enabling informed consent.
• French speaker

Exclusion criteria:

• Legal protection
• Pregnancy or breastfeeding
• History of bariatric surgery (except gastric banding, provided it was removed more than five years ago).
• Acute or progressive chronic disease
• Alcohol consumption of more than 20 g/day
• Inflammatory bowel disease;
• Digestive autonomic diabetic neuropathy.
• Consumption of dietary supplements (stanols, probiotics, prebiotics or omega-3).
• Following a vegan or gluten-free diet or being lactose intolerant.
• Fibre consumption >30 g/day
• Recent change in antidiabetic medication within the past 3 months.