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As with other nutritional strategies, the clinical response to bariatric surgery can be highly variable, with weight regain being a frequent occurrence. Recent evidence on anti-obesity medication indicate similar inter-individual variability in clinical response. Among multiples factors, co-occurrence of eating disorders such as binge eating disorder has been implicated in insufficient clinical response. Improving our ability to predict how patients will respond to obesity treatment is necessary in order to tailor the care pathways we offer. The mechanisms involved in disturbances of eating behaviour before and after surgery remain largely unknown. This study aims to identify the predictive factors of weight loss after pharmacological or surgical treatment, as well as the cognitive and biological mechanisms that mediate this effect.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pharmacological or surgical treament of obesity | Procedure | Longitudinal follow-up of participants who initiate an anti-obesity medication or whose application for bariatric surgery was accepted. It will combine anthropometric, clinical, neuropsychological and biological measurements taken at various timepoints. Participants will be asked to complete a set of online questionnaires and data will be recorded anonymously. Biological samples will be collected at various time points. |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between weight loss after treatment and clinical, neuropsychological and biological parameters. | The percentage of excessive weight loss after treatment will be correlated with
| Throughout the entire study, aproximately during 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Binge Eating Disorder. | Evaluation of eating disorders using the Binge Eating Scale (BES). | Throughout the entire study, aproximately during 5 years |
| Food Addiction. | Evaluation of food addiction will be performed using modified Yale Food Addiction Scale 2.0. |
| Measure | Description | Time Frame |
|---|---|---|
| Sociodemographic data | Number of children and marital status will be recorded | Once at inclusion |
| Medical history | Information concerning medical comorbidities will be collected from the patient medical record. |
Inclusion criteria:
Exclusion criteria:
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Participants initiating an anti-obesity medication or candidates for bariatric surgery once its indication has been validated by a multidisciplinary committee, following medical, nutritional and psychological evaluations.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Pr Amandine Everard, Professor | Contact | + 32 (0)2 436 22 10 | +32 | amandine.everard@uclouvain.be |
| Yannick Deswysen, Doctor | Contact | + 32 2 764 22 13 | +32 | yannick.deswysen@saintluc.uclouvain.be |
| Name | Affiliation | Role |
|---|---|---|
| Amandine Everard, Professor | Université Catholique de Louvain | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cliniques Universitaires Saint-Luc | Recruiting | Brussels | Brussels Capital | 1200 | Belgium |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D050177 | Overweight |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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| Throughout the entire study, aproximately during 5 years |
| Eating attitudes | Eating patterns and habits will be screened using the Eating Attitude Test 26 | Throughout the entire study, aproximately during 5 years |
| Cognitive flexibility. | Neuropsychological evaluation of cognitive flexibility will be performed with the Trail Making Test | Throughout the entire study, aproximately during 5 years |
| Impulsivity. | Impulsivity will be assessed using the Barrat Impulsiveness Scale (BIS) | Throughout the entire study, aproximately during 5 years |
| Self-reported quality of life. | Self-reported quality of life will be assessed using the QOLOD (Quality of Life, Obesity and Dietetics) | Throughout the entire study, aproximately during 5 years |
| Obesity. | Weight will be measured at each timepoint | Throughout the entire study, aproximately during 5 years |
| Physical activity. | Weekly physical activity will be reported with the Godin Leisure Time Exercise Questionnaire (GLTEQ) | Throughout the entire study, aproximately during 5 years |
| Food intake. | Eating habits will be recorded with a Food Frequency Questionnaire (FFQ) | Throughout the entire study, aproximately during 5 years |
| Blood samples | Blood samples will be collected and processed for metabolomic analyses. | Throughout the entire study, aproximately during 5 years |
| Fecal sample | Feces samples will be collected and processed to evaluation gut-microbiota composition | Throughout the entire study, aproximately during 5 years |
| Once at inclusion |
| Childhood Trauma. | Assessment of adverse life events and trauma will used the Childhood Trauma Questionnaire - short form. | Once at inclusion |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |