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| Name | Class |
|---|---|
| U.S. National Science Foundation | FED |
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The aim of this study was to investigate to what extent PD affects the ability to walk, respond to balance perturbations (i.e., Protective Step Training) and produce acute short-term effects to improve compensatory reactions and control of unperturbed walking balance.
Understanding the mechanism of compensation and neuroplasticity to unexpected step perturbation training during walking and static stance can have positive implications on the treatment of PD by helping to design effective training paradigms that remediate fall risk. Current rehabilitation therapies are inadequate at reducing falls in people with Parkinson's disease (PD). While pharmacologic and surgical treatments have proved largely ineffective in treating postural instability and gait dysfunction in people with PD, studies have demonstrated that therapy specifically focusing on posture, gait, and balance may significantly improve these factors and reduce falls. The primary goal of this study was to assess the effectiveness of a novel and promising intervention therapy (protective step training - i.e., PST - balance disturbance/perturbation during treadmill walking) to improve balance as measured by the reaction time and reduce falls in people with PD. A secondary goal was to understand the effects of PST on proactive and reactive feedback responses during stance and gait tasks. Multi-baseline, repeated measures analyses were performed on the multitude of proactive and reactive performance measures to assess the effects of PST on gait and postural stability parameters.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Standing Perturbation Protocol | Experimental | Different postural perturbations were administered - while walking and while standing. |
|
| Walking Perturbation Protocol | Experimental | Different postural perturbations were administered - while walking and while standing. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Protective Step Training | Behavioral | Perturbation during standing and walking to actively assess proactive as well as reactive motor adaptations. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Joint (knee) reaction time | Joint (knee) Reaction time during standing and walking perturbations. | one year |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Glencroft Senior Living: Retirement Community in Arizona | Glendale | Arizona | 85302 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37965161 | Result | Lockhart T, Frames C, Olson M, Moon SH, Peterson D, Lieberman A. Effects of protective step training on proactive and reactive motor adaptations in Parkinson's disease patients. Front Neurol. 2023 Oct 24;14:1211441. doi: 10.3389/fneur.2023.1211441. eCollection 2023. |
| Label | URL |
|---|---|
| Frontiers Journal Manuscript | View source |
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Crossover design:
Prior to testing, subjects were randomly assigned to two groups. One group started with postural perturbation (PP) training (during stance), while the other group began with gait perturbation (GP) training before crossing over (during walking). During this onboarding period, self-reported and observed leg dominance in bilateral mobilizing was utilized to determine the dominant leg that will be perturbed in the walking trials. Investigators described a scenario for the participant in which they were asked which leg they would use to kick a ball over the ground.
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Randomized the all walking/training trials
|
| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
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