Clinical Investigation of Oral Malodor for Max Fresh Toothpaste Containing Zinc Citrate Versus a Commercially Available Regular Fluoride Toothpaste

Clinical Investigation of Oral Malodor for Max Fresh Toothpaste Containing Zinc Citrate Versus a Commercially Available Regular Fluoride Toothpaste Using the Organoleptic Method: a Three-week Study in China

The objective of this three-week clinical research study is to evaluate oral malodor for a toothpaste containing zinc citrate as compared to a commercially available regular fluoride toothpaste using the organoleptic method.

Inclusion Criteria:

• Adults aged 18-70 years, inclusive.
• Availability for the full three-week duration of the study.
• Good general health.
• Initial mean oral malodor (organoleptic) score ≥ 6.0 and ≤ 8.4.
• Signed informed consent form.

Exclusion Criteria:

• Presence of orthodontic bands.
• Tumors of the soft or hard tissues of the oral cavity.
• Advanced periodontal disease (e.g., purulent exudate, tooth mobility, and/or extensive loss of periodontal attachment or alveolar bone).
• Five (5) or more carious lesions requiring immediate restorative treatment.
• Use of antibiotics within one (1) month prior to study entry.
• Participation in any other clinical study or test panel within one (1) month prior to study entry.
• Dental prophylaxis within two (2) weeks prior to the initial examination.
• History of allergies to oral care/personal care products or their ingredients.
• Use of prescription medications that might interfere with study outcomes.
• Medical condition that prevents fasting (no food or drink) for up to four (4) hours.
• History of drug and/or alcohol abuse.
• Pregnant or lactating (self-reported).