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Oligometastatic breast cancer is a condition in which breast cancer has spread to a small number of other parts of the body. Patients with this type of disease may live longer than those with more widespread metastases. In addition to standard treatments that act on the whole body, such as chemotherapy or hormonal therapy, these patients might also benefit from local treatments that directly target the cancer spots. One of these local treatments is stereotactic body radiotherapy (SBRT), a non-invasive radiation treatment that delivers high doses of radiation in a few sessions. In the past, most of the evidence about the benefit of local treatments came from surgery. More recently, there has been growing interest in SBRT because it does not require surgery. However, the results of studies so far have not been consistent.The goal of this multicenter retrospective study is to better understand whether SBRT can improve disease control and survival in patients with breast cancer that has spread to a limited number of sites outside the brain.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| TREATMENT SBRT | patients who have been treated with stereotactic radiotherapy to oligometastatic sites |
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| Measure | Description | Time Frame |
|---|---|---|
| progression free survival | years of survival without disease progression assessed by imaging | from January 2010 to December 2023 |
| Measure | Description | Time Frame |
|---|---|---|
| Local Control | time between treatment and disease recurrence assessed by imaging | from January 2010 to December 2023 |
| overall survival | the time from diagnosis or initiation of treatment until death from any cause |
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Inclusion Criteria:
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Patient with Oligometastatic or oligoprogressive metastatic breast cancer treated with SBRT
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ruggero Spoto, MD, Radiation oncologist | Contact | +39 0282248508 | ruggero.spoto@cancercenter.humanitas.it | |
| Laura Bonavita, Master Degree | Contact | +39 0282247026 | laura.bonavita@humanitas.it |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aorn San Pio | Not yet recruiting | Benevento | Benevento | 82100 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36549169 | Background | van Ommen-Nijhof A, Steenbruggen TG, Capel L, Vergouwen M, Vrancken Peeters MT, Wiersma TG, Sonke GS. Survival and prognostic factors in oligometastatic breast cancer. Breast. 2023 Feb;67:14-20. doi: 10.1016/j.breast.2022.12.007. Epub 2022 Dec 14. | |
| Background | K. A. W. W. A. W. V. F. B. J. K. Steven J. Chmura, "NRG-BR002: A phase IIR/III trial of standard of care systemic therapy with or without stereotactic body radiotherapy (SBRT) and/or surgical resection (SR) for newly oligometastatic breast cancer," ASCO, 2022 | ||
| 35643253 |
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| From January 2010 to December 2023 |
| acute and late toxicity RT related | Evaluation of toxicities related to radiotherapy treatment using the scale CTCAE (Grade 1: Mild, Grade 2: Moderate, Grade 3: Severe, Grade 4: Life-threatening, Grade 5: Death) | from January 2010 to December 2023 |
| Humanitas Gavazzeni | Recruiting | Bergamo | Bergamo | 24125 | Italy |
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| Ospedale Perrino | Not yet recruiting | Brindisi | BR | 72100 | Italy |
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| Spedali Civili | Recruiting | Brescia | BS | 25123 | Italy |
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| Responsible Research Hospital | Recruiting | Campobasso | CB | 86100 | Italy |
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| Azienda Ospedaliera Universitaria Careggi | Not yet recruiting | Florence | Firenze | 50134 | Italy |
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| Irccs Ospedale Policlinico San Martino | Not yet recruiting | Genova | Genova | 16132 | Italy |
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| A.O.U. "G. Martino" - Università degli Studi di Messina | Not yet recruiting | Messina | Messina | 98124 | Italy |
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| Fondazione I.R.C.C.S Istituto Nazionale Tumori di Milano | Recruiting | Milan | MILANO | 20133 | Italy |
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| IEO | Not yet recruiting | Milan | Milano | 20141 | Italy |
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| IRCCS Humanitas Research Humanitas | Recruiting | Rozzano | MILANO | 20089 | Italy |
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| IRCCS Ospedale San Raffaele | Not yet recruiting | Milan | Milan | 20132 | Italy |
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| INT IRCCS Fondazione G. Pascale | Recruiting | Naples | Napoli | 80131 | Italy |
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| Ospedale Maggiore della Carita | Recruiting | Novara | NOVARA | 28100 | Italy |
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| Civico Palermo | Not yet recruiting | Palermo | Palermo | 90127 | Italy |
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| Istituto Oncologico Veneto | Not yet recruiting | Padova | PD | 35128 | Italy |
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| Azienda Ospedaliera Universitaria Pisana | Not yet recruiting | Pisa | PI | 56124 | Italy |
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| IRCCS Centro di Riferimento Oncologico di Aviano | Not yet recruiting | Aviano | Pordenone | 33081 | Italy |
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| Uo Radioterapia Aor San Carlo | Not yet recruiting | Potenza | PZ | 85100 | Italy |
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| Irccs Crob | Recruiting | Rionero in Vulture | PZ | 85028 | Italy |
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| UOC Radioterapia Ospedale San Filippo Neri | Not yet recruiting | Roma | RM | 00135 | Italy |
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| Azienda Ospedaliera San Giovanni Addolorata | Not yet recruiting | Roma | RM | 00184 | Italy |
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| Fondazione Policlinico Universitario, Campus-Biomedico | Recruiting | Roma | Roma | 00128 | Italy |
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| Fondazione PTV Policlinico Tor Vergata | Not yet recruiting | Roma | Roma | 00133 | Italy |
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| Azienda Ospedaliera Sant'Andrea | Not yet recruiting | Roma | Roma | 00189 | Italy |
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| S.C. Radioterapia Oncologica ASL Taranto | Not yet recruiting | Taranto | Taranto | 74100 | Italy |
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| Radioterapia Oncologica - Ospedale Sanata Chiara | Not yet recruiting | Trento | TRENTO | 38122 | Italy |
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| S.C. Radioterapia Oncologica - Azienda Ospedaliera Santa Maria Terni | Not yet recruiting | Terni | TR | 05100 | Italy |
|
| Background |
| Harrow S, Palma DA, Olson R, Gaede S, Louie AV, Haasbeek C, Mulroy L, Lock M, Rodrigues GB, Yaremko BP, Schellenberg D, Ahmad B, Senthi S, Swaminath A, Kopek N, Liu M, Schlijper R, Bauman GS, Laba J, Qu XM, Warner A, Senan S. Stereotactic Radiation for the Comprehensive Treatment of Oligometastases (SABR-COMET): Extended Long-Term Outcomes. Int J Radiat Oncol Biol Phys. 2022 Nov 15;114(4):611-616. doi: 10.1016/j.ijrobp.2022.05.004. Epub 2022 May 26. |
| 35117868 | Background | Terao M, Niikura N. Diagnosis of oligometastasis. Transl Cancer Res. 2020 Aug;9(8):5032-5037. doi: 10.21037/tcr.2020.01.04. |
| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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