Clinical Feasibility of Full Free-Breathing Cardiac Magnetic Resonance Imaging

Full Free-Breathing Cardiac Magnetic Resonance Imaging: Clinical Feasibility, Efficiency, and Diagnostic Concordance

To evaluate the feasibility, efficiency, and diagnostic concordance of a full comprehensive free-breathing cardiac magnetic resonance protocol with motion correction and sensing.

This study aims to establish a large-scale, clinically oriented full free-breathing cardiac MRI framework to eliminate dependence on patient breath-holding, substantially shorten scan time, and improve patient comfort. Building on prior successful implementation of compressed sensing and motion correction techniques, the invesitgators will collaborate with the MRI vendor and sequence scientists to develop a comprehensive set of free-breathing sequences, including cine imaging, T1/T2 mapping, flow, perfusion, and late gadolinium enhancement (LGE). The study will then prospectively enroll a large, disease-diverse cohort of cardiovascular patients at Fuwai Hospital and systematically compare the full free-breathing protocol with conventional breath-hold protocols in terms of acquisition time, image quality, and agreement of quantitative parameters, thereby providing a comprehensive assessment of technical feasibility and clinical value.

Inclusion Criteria:

• consecutive enrollment of patients referred for clinically indicated contrast-enhanced CMR

Exclusion Criteria:

• patients with CMR contraindications