Nasojejunal Feeding Versus Oral Feeding Following Endoscopic Drainage of Walled Off Pancreatic Necrosis

Nasojejunal Feeding Versus Oral Feeding Following Endoscopic Drainage of Walled Off Pancreatic Necrosis: A Randomized Controlled Pilot Study

The goal of this randomized control trial is to assess whether nasojejunal feed is better than oral nutrition in patients who are undergoing endoscopic cystogastrostomy of walled off necrosis following acute pancreatitis. It will also try to answer, the incidence of infections and feed tolerance.

The main question it tries to answer is

1. whether nasojejunl feed is better than oral feed in patients undergoing endoscopic cystogastrostomy in walled off necrosis following acute pancreatitis
2. How much infections they develop, whether they are able to tolerate the feed, weight gain and reintervention rates in each group

Inclusion Criteria:

1. Patients of acute pancreatitis (AP) with 18-75 years of age
2. Patients with symptomatic WON requiring EUS guided transluminal drainage
3. Provision of written informed consent

Exclusion Criteria:

1. Patients with collection not amenable for EUS guided drainage (distance of WON >1 cm from the gastrointestinal lumen)
2. Known malignancy or immunocompromised state
3. Previous upper gastrointestinal(GI) surgery interfering with absorption
4. Active GI bleeding
5. GI obstruction, ileus or persistent vomiting
6. Patients moribund to undergo endoscopic procedure (Glasgow coma scale <8 or patients on ventilatory support)
7. Patients with irreversible coagulopathy like platelets <50,000/mm3 and/or INR>1.5
8. Pregnant or lactating female