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The goal is to determine whether three months of at least three times / week of sensory flicker stimulation improves cognition, mobility, and affect in healthy older adults and older adults with and without Subjective Cognitive Decline (SCD). Investigators will also determine whether the intervention slows cortical thinning and declines in brain functional network segregation and changes in blood biomarkers of Alzheimer's Disease (AD).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Sham Comparator | Participants in this group will receive control stimulation rather than a constant flicker frequency. |
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| Flicker Stimulation - Infrared | Experimental | Participants in this group will receive infrared sensory visual flicker stimulation. |
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| 18 Hz Visual Occlusion | Experimental | Participants will wear visual occlusion glasses with visible flickering at 18 Hz. |
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| Control - Visual Occlusion | Sham Comparator | Participants will receive visual stimulation at a control frequency of 1 Hz. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Flicker Stimulation | Behavioral | Investigators will utilize near-infrared two-photon stimulation (890-940 nm) to deliver rhythmic input in a subliminal, comfortable manner, without the side effects associated with visible flicker. |
| Measure | Description | Time Frame |
|---|---|---|
| Cognition | Investigators will comprehensively assess behavior at three times (baseline, half-way through (1.5 months), and after the intervention (3months)) using the TabCAT. Composite Scores will serve as primary metrics for cognition. | Baseline, halfway through (1.5 months), and post-intervention (3 months) |
| Grip strength | Participants will grip a machine which measures their grip strength in kg. | Baseline, halfway through (1.5 months), and post-intervention (3 months) |
| 10m Gait Speed | Participants will walk unassisted for 10 meters. Their speed will be measured in seconds. | Baseline, halfway through (1.5 months), and post-intervention (3 months) |
| Clinical Test of Sensory Interaction on Balance (CTSIB) | Participants will, with eyes open and closed, walk on rough and smooth terrain. Investigators will measure sway area (measured in m^2/s^4). | Baseline, halfway through (1.5 months), and post-intervention (3 months) |
| Affect - POMS-2 | This test is used to assess transient feelings and mood among individuals aged 13 years and above. Scoring: 0 - Not at all
Except "Relaxed" and "Efficient", and they score the reverse: | Baseline, halfway through (1.5 months), and post-intervention (3 months) |
| Affect - Ryff Scales of Psychological Wellbeing | Respondents agree or disagree with 42 statements using a 6-point scale (1 = strongly agree; 6 = strongly disagree). |
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Inclusion Criteria:
Additional Inclusion Criteria for SCD:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rachael Seidler | Contact | 7348340385 | rachaelseidler@ufl.edu |
| Name | Affiliation | Role |
|---|---|---|
| Rachael Seidler | University of Florida | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Florida | Gainesville | Florida | 32611 | United States |
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| Control Stimulation | Behavioral | The control group will receive a control stimulation rather than a constant flicker frequency. |
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| 18 Hz Visual Occlusion | Behavioral | The participants will wear visual occlusion glasses with visible stimulation flickering at 18 Hz |
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| Control - Visual Occlusion | Behavioral | Participants will receive visible stimulation at a frequency that is 1 Hz. |
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| Baseline, halfway through (1.5 months), and post-intervention (3 months) |
| Affect - Satisfaction with Life Scale | The possible range of scores is 5-35. Scores between 5-9 indicate the respondent is extremely dissatisfied with life, whereas scores between 31-35 indicate the respondent is extremely satisfied. | Baseline, halfway through (1.5 months), and post-intervention (3 months) |
| Affect - Perceived Stress Scale | Score is obtained by reverse-scoring items 4, 5, 7, and 8 and then summing the scores. | Baseline, halfway through (1.5 months), and post-intervention (3 months) |
| Affect - Apathy Evaluation Scale | After recoding all necessary items, sum up all scores. | Baseline, halfway through (1.5 months), and post-intervention (3 months) |
| Affect - TabCAT Dynamic Affect Recognition Test (DART) task | The examinee is shown videos depicting realistic non-verbal emotional cues, and is asked to identify the emotion that the character displayed in the video. | Baseline, midpoint (1.5 months), and post-intervention (3 months) |
| Affect - TabCAT Social Interaction Vocabulary Test (SIVT) task | The examinee is given a word describing a socioemotional interaction and is asked to choose a picture that best represents the meaning of the word. | Baseline, midpoint (1.5 months), and post-intervention (3 months) |
| Brain Structure and Network Function | Investigators will assess brain structure via a T1 MRI to measure cortical thickness in dorsolateral prefrontal, sensorimotor, and insular cortices using the CAT computational anatomy toolbox; brain network function via resting-state fMRI to capture functional segregation of dorsolateral prefrontal, sensorimotor, and insular networks (subserving cognition, mobility, and affect respectively) using the CONN toolbox. | Baseline, halfway through (1.5 months), and post-intervention (3 months) |
| Blood-based AD pathology (Aβ17) | Investigators will assess levels of Aβ17 [units], which is sensitive to AD. Blood samples will be processed on campus by UF's Florida Alzheimer's Disease Research Center Biomarker Core. Blood will be centrifuged and placed into -80°C storage maintained by the PIs. Coded blood samples will be analyzed in the final year of this project. These biomarker levels will not be shared with participants, as this is not a diagnostic laboratory. | Baseline, halfway through (1.5 months), and post-intervention (3 months) |
| Blood-based AD pathology [p-tau] | Investigators will assess levels of p-tau [units], which is sensitive to AD. Blood samples will be processed on campus by UF's Florida Alzheimer's Disease Research Center Biomarker Core. Blood will be centrifuged and placed into -80°C storage maintained by the PIs. Coded blood samples will be analyzed in the final year of this project. These biomarker levels will not be shared with participants, as this is not a diagnostic laboratory. | Baseline, halfway through (1.5 months), and post-intervention (3 months) |