Surgical Handling of Fertility-preserving Treatments for Cervical Adenocarcinomas

Surgical Handling of Fertility-preserving Treatments for Cervical Adenocarcinomas

Despite a growing body of literature on the subject, there is still uncertainty regarding direct comparisons between different conservative surgical techniques for cervical adenocarcinomas. In particular, it remains unclear whether fertility-sparing surgery for cervical adenocarcinomas - characterized by skip lesions - can ensure optimal disease control while achieving adequate obstetric outcomes.

For this reason, a systematic review and meta-analysis of the literature, along with an analysis of our center's data, is warranted. This approach will allow a critical, comparative evaluation of the efficacy of the different techniques (conization, simple trachelectomy, and radical trachelectomy) and the identification of prognostic factors to guide therapeutic choice.

Inclusion Criteria:

• Adult women of reproductive age with a diagnosis of cervical adenocarcinoma
• Undergoing fertility-sparing surgery
• Minimum 12-month follow-up
• Signed informed consent

Exclusion Criteria:

• Histotypes other than cervical adenocarcinoma
• Undergoing radical surgery
• Follow-up less than 12 months