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Despite a growing body of literature on the subject, there is still uncertainty regarding direct comparisons between different conservative surgical techniques for cervical adenocarcinomas. In particular, it remains unclear whether fertility-sparing surgery for cervical adenocarcinomas - characterized by skip lesions - can ensure optimal disease control while achieving adequate obstetric outcomes.
For this reason, a systematic review and meta-analysis of the literature, along with an analysis of our center's data, is warranted. This approach will allow a critical, comparative evaluation of the efficacy of the different techniques (conization, simple trachelectomy, and radical trachelectomy) and the identification of prognostic factors to guide therapeutic choice.
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| Measure | Description | Time Frame |
|---|---|---|
| Recurrence rate | The recurrence rate is defined as the proportion of patients who develop disease recurrence confirmed by imaging or histopathologic evaluation after FSS. | 5 years |
| Disease free survival | Disease-free survival is defined as the time from surgery until the first documented recurrence. | 5 years |
| Overall survival | Overall survival is measured as the time from surgery to death from any cause, | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| pregnancy rate | Pregnancy rate is defined as the proportion of patients who achieve a clinically confirmed pregnancy among those attempting conception | 5 years |
| live birth rate | Live birth rate is defined as the percentage of pregnancies that result in a live birth. |
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Inclusion Criteria:
Exclusion Criteria:
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Adult women of reproductive age with cervical adenocarcinoma undergoing fertility-sparing surgery (conization, simple trachelectomy, radical trachelectomy) between 01/06/2019 and 30/06/2024
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Matteo Pavone, MD, PhDc | Contact | +390630151 | matteo.pavone@guest.policlinicogemelli.it |
| Name | Affiliation | Role |
|---|---|---|
| Nicolò Bizzarri | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Roma | 00100 | Italy |
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| ID | Term |
|---|---|
| D002583 | Uterine Cervical Neoplasms |
| ID | Term |
|---|---|
| D014594 | Uterine Neoplasms |
| D005833 | Genital Neoplasms, Female |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
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| 5 years |
| D009369 |
| Neoplasms |
| D002577 | Uterine Cervical Diseases |
| D014591 | Uterine Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |