Intradermal Acupuncture for Assisting SSRI Dose Reduction in Major Depressive Disorder

Clinical Efficacy of Intradermal Acupuncture as an Adjunct to SSRI Dose Reduction or Discontinuation in Patients With Major Depressive Disorder and Its Mechanisms of Autonomic Nervous System Regulation

This randomized controlled trial aims to evaluate the clinical efficacy of intradermal acupuncture as an adjunctive intervention to assist selective serotonin reuptake inhibitor (SSRI) dose reduction or discontinuation in adult patients with major depressive disorder (MDD). Participants receiving SSRIs and planning gradual dose reduction or discontinuation will be randomly assigned to one of three groups: SSRI tapering alone, sham intradermal acupuncture plus SSRI tapering, or intradermal acupuncture plus SSRI tapering. Clinical outcomes and autonomic nervous system function will be assessed to determine the effectiveness and potential mechanisms of intradermal acupuncture in facilitating SSRI reduction and alleviating withdrawal-related symptoms.

Inclusion Criteria:

• Adults aged 18-60 years

Diagnosis of major depressive disorder according to DSM-5

Currently receiving SSRI treatment and planning gradual dose reduction or discontinuation

Clear consciousness and ability to communicate normally

Willingness to participate and provide written informed consent

Exclusion Criteria:

• Severe uncontrolled primary medical conditions

Depression secondary to substances, medical illness, other psychiatric disorders (e.g., bipolar disorder, schizophrenia), or major bereavement

Active suicidal ideation

Pregnancy or lactation

Cognitive impairment

Bleeding disorders or allergy to adhesive materials

Participation in another clinical trial within the past month