Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The goal of this clinical trial is to learn if repeated transcranial magnetic stimuli (rTMS) can treat stuttering in adults. The main questions it aims to answer are:
Participants will:
Measures must be obtained to in preparation for TMS treatment. Structural MRI and resting-state functional MRI (rsfMRI) recordings will be obtained from the participant, and they will undergo a neuronavigational session to determine best placement for the electrodes.
MRI/rsfMRI recordings: The structural MRIs will be obtained and used for TMS neuronavigation. Resting-state functional MRI will be recorded for 8 min with the eyes open. rTMS will be delivered at 10 Hz for 10 min with a stimulation intensity of 120% of the resting motor threshold (rMT).
Neuronavigation: The TMS coil will be navigated with a neuronavigation system using the individual MRIs. rTMS targets: rTMS will be delivered to the left inferior frontal gyrus (IFG). We will use the neuronavigation system to identify the IFG.
Three pre-treatment and 2 post-treatment sessions will each obtain data from the following measurements:
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Transcranial Magnetic Stimulation to treat stuttering | Experimental | There is only one arm to this study. All participants will receive 10 days of Transcranial Magnetic Stimulation to specific cortical speech and motor areas. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial Magnetic Stimulation | Device | This study uses Transcranial Magnetic Stimulation (TMS) applied to specific speech and motor areas of the brain to stimulate cortical areas that experience reduced activations during left-hemisphere dominant tasks in people who stutter. |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in functional connectivity with resting-state electroencephalography (rs-EEG) | A seed-based functional connectivity analysis will be carried out between the two stimulated brain areas. To assess the changes in effective connectivity, the investigators will compare the seed-based connectivity values across sessions. | Baseline, immediately post-treatment, and one week after post-treatment. |
| Changes in behavioral measures of stuttering and phonological processing. | To assess functional changes as a result of rTMS treatment, comparison of eye tracking measurements of duration, dwell time, and number of fixations of eye movements while completing speech and language-based tasks are compared across sessions. | Baseline, immediately post-treatment, and one week after post-treatment. |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kristin Pelczarski, Ph.D. | Contact | 785-532-6879 | kpelczar@ksu.edu | |
| Julio Hernandez Pavon, Ph.D., DSc | Contact | juliohpavon@ksu.edu |
| Name | Affiliation | Role |
|---|---|---|
| Kristin Pelczarski, Ph.D. | Kansas State University | Principal Investigator |
| Julio Hernandez Pavon, Ph.D., DSc | Kansas State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bluemont Hall, Department of Psychological Sciences, Kansas State University | Recruiting | Manhattan | Kansas | 66506-7500 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17565358 | Background | Ridding MC, Rothwell JC. Is there a future for therapeutic use of transcranial magnetic stimulation? Nat Rev Neurosci. 2007 Jul;8(7):559-67. doi: 10.1038/nrn2169. | |
| 30954150 | Background | Hernandez-Pavon JC, Harvey RL. Noninvasive Transcranial Magnetic Brain Stimulation in Stroke. Phys Med Rehabil Clin N Am. 2019 May;30(2):319-335. doi: 10.1016/j.pmr.2018.12.010. Epub 2019 Feb 21. |
Not provided
Not provided
IPD used in the results publication with be shared with other researchers.
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D013342 | Stuttering |
| ID | Term |
|---|---|
| D013064 | Speech Disorders |
| D007806 | Language Disorders |
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
Not provided
Not provided
| ID | Term |
|---|---|
| D050781 | Transcranial Magnetic Stimulation |
| ID | Term |
|---|---|
| D055909 | Magnetic Field Therapy |
| D013812 | Therapeutics |
Not provided
Not provided
Repeated measures, single subject design
Not provided
Not provided
Not provided
Not provided
|
| 36828303 | Background | Hernandez-Pavon JC, Veniero D, Bergmann TO, Belardinelli P, Bortoletto M, Casarotto S, Casula EP, Farzan F, Fecchio M, Julkunen P, Kallioniemi E, Lioumis P, Metsomaa J, Miniussi C, Mutanen TP, Rocchi L, Rogasch NC, Shafi MM, Siebner HR, Thut G, Zrenner C, Ziemann U, Ilmoniemi RJ. TMS combined with EEG: Recommendations and open issues for data collection and analysis. Brain Stimul. 2023 Mar-Apr;16(2):567-593. doi: 10.1016/j.brs.2023.02.009. Epub 2023 Feb 23. |
| 29976115 | Background | Pelczarski KM, Tendera A, Dye M, Loucks TM. Delayed Phonological Encoding in Stuttering: Evidence from Eye Tracking. Lang Speech. 2019 Sep;62(3):475-493. doi: 10.1177/0023830918785203. Epub 2018 Jul 6. |
| 27280891 | Background | Pelczarski KM, Yaruss JS. Phonological memory in young children who stutter. J Commun Disord. 2016 Jul-Aug;62:54-66. doi: 10.1016/j.jcomdis.2016.05.006. Epub 2016 May 17. |
| 24759190 | Background | Pelczarski KM, Yaruss JS. Phonological encoding of young children who stutter. J Fluency Disord. 2014 Mar;39:12-24. doi: 10.1016/j.jfludis.2013.10.003. Epub 2013 Nov 20. |
| 25680736 | Background | Byrd CT, McGill M, Usler E. Nonword repetition and phoneme elision in adults who do and do not stutter: Vocal versus nonvocal performance differences. J Fluency Disord. 2015 Jun;44:17-31. doi: 10.1016/j.jfludis.2015.01.004. Epub 2015 Jan 24. |
| 16814376 | Background | Anderson JD, Wagovich SA, Hall NE. Nonword repetition skills in young children who do and do not stutter. J Fluency Disord. 2006;31(3):177-99. doi: 10.1016/j.jfludis.2006.05.001. Epub 2006 Jun 30. |
| 18442810 | Background | Strand F, Forssberg H, Klingberg T, Norrelgen F. Phonological working memory with auditory presentation of pseudo-words -- an event related fMRI Study. Brain Res. 2008 May 30;1212:48-54. doi: 10.1016/j.brainres.2008.02.097. Epub 2008 Mar 18. |
| 28631005 | Background | Perrachione TK, Ghosh SS, Ostrovskaya I, Gabrieli JDE, Kovelman I. Phonological Working Memory for Words and Nonwords in Cerebral Cortex. J Speech Lang Hear Res. 2017 Jul 12;60(7):1959-1979. doi: 10.1044/2017_JSLHR-L-15-0446. |
| 29228195 | Background | Neef NE, Anwander A, Butfering C, Schmidt-Samoa C, Friederici AD, Paulus W, Sommer M. Structural connectivity of right frontal hyperactive areas scales with stuttering severity. Brain. 2018 Jan 1;141(1):191-204. doi: 10.1093/brain/awx316. |
| 25595146 | Background | Neef NE, Hoang TN, Neef A, Paulus W, Sommer M. Speech dynamics are coded in the left motor cortex in fluent speakers but not in adults who stutter. Brain. 2015 Mar;138(Pt 3):712-25. doi: 10.1093/brain/awu390. Epub 2015 Jan 15. |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |