This study is a Phase I randomized clinical trial aiming to investigate the short-term effects of three commonly prescribed statins i.e (Atorvastatin, Rosuvastatin, and Simvastatin) at different dose levels i.e lo,median and high doses on cardiovascular parameters i.e Blood pressure and ECG morphology in healthy volunteers. The study will assess changes in blood pressure and ECG morphology following two days of statin administration under controlled conditions.

The goal of this study is to evaluate the effects of these three statins on the cardiovascular parameters in a dose-dependent manner. In this Phase 1 clinical trial we will enroll healthy volunteers who will be randomized to receive one of three statins at low, moderate, or high doses for two days. .

Inclusion Criteria:

• Healthy volunteers
• Normal ECG
• Normal Blood Pressure
• Normal lipid levels

Exclusion Criteria:

• Participants with a history of diabetes mellitus,BP
• With chronic diseases e.g heart disease, kidney disease
• QTc ≥450 ms (men) or ≥470 ms (women)
• ECG changes
• Electrolyte imbalance,
• Participants taking other medications

The study results will be shared in well reputable Journals without the participant identifiers

The PI will give the assigned medication to each participant according to randomization and allocation. All the personnel involved in the study will be kept blind.