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This study aims to compare standard positive end-expiratory pressure (PEEP) with dynamic compliance-guided individualized PEEP in obese patients undergoing elective spinal surgery under general anesthesia. Obesity and prone positioning during spinal surgery are associated with reduced lung compliance, atelectasis, and an increased risk of postoperative pulmonary complications.
Participants will be allocated to receive either a fixed standard PEEP or an individualized PEEP level determined according to intraoperative dynamic lung compliance. Intraoperative oxygenation, respiratory mechanics, arterial blood gas parameters, and hemodynamic variables will be assessed at predefined time points. Postoperative pulmonary complications within the first 24 hours after surgery will also be evaluated.
The study seeks to determine whether individualized PEEP titration based on dynamic compliance offers physiological or clinical advantages compared with a standard PEEP strategy in this patient population.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Standard PEEP | Active Comparator | Patients assigned to this arm receive a fixed positive end-expiratory pressure (PEEP) of 5 cmH₂O throughout the intraoperative period during mechanical ventilation. |
|
| Dynamic Compliance-Guided Individualized PEEP | Experimental | Patients assigned to this arm receive individualized positive end-expiratory pressure (PEEP) titrated according to intraoperative dynamic lung compliance, with the aim of optimizing respiratory mechanics while avoiding overdistension. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Standard PEEP | Device | Application of a fixed positive end-expiratory pressure of 5 cmH₂O during intraoperative mechanical ventilation. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Intraoperative Oxygenation (PaO₂/FiO₂ Ratio) | The primary outcome is intraoperative oxygenation assessed by the arterial partial pressure of oxygen to fraction of inspired oxygen (PaO₂/FiO₂) ratio during mechanical ventilation. | From induction of anesthesia until the end of surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Dynamic Lung Compliance | Dynamic lung compliance (mL/cmH₂O) measured intraoperatively via ventilator respiratory mechanics monitoring. | From induction of anesthesia until the end of surgery |
| Static Lung Compliance |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Konya City Hospital | Konya | 42090 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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Participants are assigned to one of two parallel groups receiving either standard fixed PEEP or dynamic compliance-guided individualized PEEP during surgery.
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Static lung compliance (mL/cmH₂O) measured intraoperatively via ventilator plateau pressure analysis.
| From induction of anesthesia until the end of surgery |
| Peak Airway Pressure | Peak inspiratory airway pressure (cmH₂O) measured intraoperatively using ventilator monitoring. | From induction of anesthesia until the end of surgery |
| Plateau Airway Pressure | Plateau airway pressure (cmH₂O) measured intraoperatively during mechanical ventilation. | From induction of anesthesia until the end of surgery |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |