Large-Scale Study of Oro-esophageal Feeding Versus Nasogastric Feeding for Swallowing Function and Airway Protection

The Effect of Oro-esophageal Versus Nasogastric Feeding for Stroke Patients With Dysphagia: A Multicenter Randomized Controlled Large-Scale Study

This is a randomized controlled trial involving patients with ischemic stroke and dysphagia. The aim of this study is to explore the recovery speed and therapeutic effect of oro-esophageal feeding compared with nasogastric feeding on swallowing function. This study mainly addresses the following two research questions: 1. Whether oro-esophageal feeding improves swallowing function more rapidly and effectively than nasogastric tube feeding. 2. Whether oro-esophageal feeding is non-inferior to nasogastric tube feeding in terms of safety.

This is a randomized controlled trial involving patients with ischemic stroke and dysphagia. The aim of this study is to explore the recovery speed and therapeutic effect of oro-esophageal feeding compared with nasogastric feeding on swallowing function. This study mainly addresses the following two research questions: 1. Whether oro-esophageal feeding improves swallowing function more rapidly and effectively than nasogastric tube feeding. 2. Whether oro-esophageal feeding is non-inferior to nasogastric tube feeding in terms of safety.

The intervention period will last for two weeks, with an additional four-week follow-up observation period. This is a multicenter study to be conducted across multiple hospitals.

Inclusion Criteria:

• Age>18 years.
• First stroke
• Disease duration less than one month.
• Ischemic stroke.
• Patients who need enteral feeding.
• Dysphagia confirmed by imaging Study.
• Clear consciousness.
• Stable vital signs.
• With informed consent and participants who understand and agree to comply with planned study procedures.

Exclusion Criteria:

• Dysphagia that might be caused by other diseases or structural abnormalities.
• Complicated with severe liver and kidney failure, tumors, or hematological disorders.
• Contraindications for tube feeding.
• Pregnancy or breast feeding.
• Anticipated discharge from the hospital or transfer to another hospital within two week.