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The purpose of this study is to assess dyadic physiological coherence and subjective empathic attunement during meditation practices and their association with opioid-related outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Meditation | Experimental | 20 minutes of guided meditation during the laboratory session involving mindfulness of breathing and lovingkindness practice. |
|
| Psychoeducation | Active Comparator | Psychoeducation about opioid neuropharmacology. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Meditation | Behavioral | 20 minutes of guided meditation during the laboratory session involving mindfulness of breathing and lovingkindness practice. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Neurophysiological synchrony | Dyadic Neural Synchrony (DNS) across electrodes and dyads will be computed from EEG oscillations using established inter-brain connectivity metrics. DNS will be quantified as a dyadic coupling parameter computed from time-series features extracted from each participant's EEG activity. Higher DNS values indicate greater therapist-patient neural attunement. | During the intervention and for 5 minutes afterwards |
| Measure | Description | Time Frame |
|---|---|---|
| Interpersonal Attunement | Interpersonal attunement measured by the Interpersonal Attunement Rating Scale, a 0-10 numeric rating scale to assess sense of connection with the other person (0=no attunement, 10=very high attunement). | During Intervention |
| Opioid Craving |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lori Kroh, BS | Contact | 619-259-0735 | l1kroh@health.ucsd.edu | |
| Kelly Hendrickson, MS | Contact | kehendrickson@health.ucsd.edu |
| Name | Affiliation | Role |
|---|---|---|
| Eric Garland, PhD | University of California, San Diego | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of California, San Diego | Recruiting | La Jolla | California | 92093 | United States |
The research team will adhere to the NIH Grants Policy on Availability of Research Results: Publications, Intellectual Property Rights, and Sharing Biomedical Research Resources.
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Data will become available after the publication of the main study findings from the final data set. Data will be made permanently available.
Data will be made available upon reasonable request with a signed data access agreement.
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| ID | Term |
|---|---|
| D019122 | Meditation |
| ID | Term |
|---|---|
| D026441 | Mind-Body Therapies |
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
| D026443 | Spiritual Therapies |
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| Psychoeducation | Behavioral | 20 minute psychoeducational script on the impact of opioid use on the brain. |
|
Opioid craving measured by 0-10 numeric rating scale (0=no craving, 10=extreme craving). |
| Pre-Intervention, during Intervention, immediately post-Intervention, and at 1 month follow-up |
| Opioid Use | Days of opioid use measured by the Timeline Followback Interview and completion of a urine drug toxicology screen. | Pre-Intervention, and 1 month Follow-Up |
| Severity of Pain | Pain rating measured by scores on Brief Pain Inventory, with higher scores indicating higher pain severity (min 0, max 10) | Pre-Intervention, during Intervention, immediately post-Intervention, and at 1 month follow-up |
| Affect | Positive and negative affect measured on a 0-10 numeric rating scale (0=low affect, 10=very high affect). | Pre-Intervention, during Intervention, and immediately post-Intervention. |
| State Self-Transcendence | Nondual awareness measured by the Nondual Awareness Dimensional Assessment Measure- State (NADA-S), with scores ranging from 0 to 30, with higher scores indicating greater self-transcendence | Pre-Intervention, during Intervention, immediately post-Intervention. |
| Metacognitive processes | Metacognitive Processes of Decentering Scale (MPODS), a 3-Item scale with scores ranging from 0 to 30, with higher scores indicating greater capacity for meta-awareness, non-reactivity, and disidentification. | Pre-Intervention, during Intervention, and immediately post-Intervention. |
| Cardiac-autonomic synchrony | Cardiac-autonomic synchrony (CAS) will be computed from heart rate variability. CAS will be quantified as a dyadic coupling parameter computed from time-series features extracted from each participant's R-R intervals. Higher CAS values indicate greater therapist-patient autonomic attunement. | During the intervention and for 5 minutes afterwards |
| Facial expression synchrony | Facial Expression Synchrony (FES) will be assessed using automated facial expression analysis derived from computer-vision-based facial landmark and action-unit detection. FES will be quantified as a dyadic coupling parameter computed from time-series features extracted from each participant's facial expressions. Higher FES values indicate greater therapist-patient affective attunement | During the intervention and for 5 minutes afterwards |
| D012064 |
| Relaxation Therapy |
| D001521 | Behavior Therapy |
| D011613 | Psychotherapy |
| D004191 | Behavioral Disciplines and Activities |