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| ID | Type | Description | Link |
|---|---|---|---|
| bahria university | Other Identifier | bahria university |
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Temporomandibular joint disorder poses an intricate etiology. Biomechanical, neuromuscular and psychosocial factors may contribute to the disorder among which psychological and psychosocial disturbances have shown strong direct or indirect contribution to the disease especially when the pain is of muscular origin.
Temporomandibular disorders (TMDs) are defined as the group of musculoskeletal and neuromuscular conditions that involves temporomandibular joint (TMJ), masticatory muscles, and their associated structures (1). Clinically, TMDs are characterized by jaw pain, mandibular movement limitation, joint sounds, and often referred pain in the head, neck, or shoulders region (2). The myofascial pain, a subtype of TMD, is most prevalent condition and it accounts for approximately 50% of all TMD cases in clinical settings (3). Although it's a prevalent condition, but its complex aetiology makes it difficult to diagnose (4).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Case | A total of 300 participants aged between 20 and 60 years were recruited using survivor sampling, consisting of 150 patients with a confirmed diagnosis of myofascial pain and temporomandibular joint dysfunction (TMD) and 150 age- and gender-matched healthy controls |
| |
| Control | A total of 300 participants aged between 20 and 60 years were recruited using survivor sampling, consisting of 150 patients with a confirmed diagnosis of myofascial pain and temporomandibular joint dysfunction (TMD) and 150 age- and gender-matched healthy controls |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Casr | Other | case study participants |
|
| Measure | Description | Time Frame |
|---|---|---|
| Psychosomatic symptom burden | Psychosomatic symptom burden is defined as the overall severity and frequency of physical symptoms that are influenced or maintained by psychological factors. It will be assessed using a validated self-report questionnaire that captures multiple somatic symptom domains (e.g., pain, gastrointestinal, cardiovascular, and fatigue-related symptoms). Higher scores indicate a greater psychosomatic symptom burden. | 2 months |
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Inclusion Criteria:
diagnosed patients with myofascial pain and TMD for at least six months based on Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD), Axis I, age between 20 and 60 years, literate and able to comprehend the questionnaire no prior psychological treatment for pain.
Exclusion Criteria:
age <20 or >60 years, low literacy (less than five years of formal education), history of major psychiatric or neurological disorders, diagnosed joint pathologies (e.g., arthritis, disc displacement with reduction), history of migraine or facial trauma, drug dependency and pregnancy or current use of psychotropic medication.
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Temporomandibular joint dysfunction patient
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| rida Zulfiqar, BDS | Contact | +923203409531 | ridazul34@gmail.com | |
| Arsalan Khalid, BDS | Contact | +923323110793 |
| Name | Affiliation | Role |
|---|---|---|
| Rida Zulfiqar | Bahria University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bahria University | Karachi | Pakistan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Result | 1. Szarejko KD, Gołębiewska M, Lukomska-Szymanska M, Kuć J. Stress experience, depression and neck disability in patients with temporomandibular disorder-myofascial pain with referral. Journal of Clinical Medicine. 2023;12(5):1988. 2. Kuć J, Szarejko KD, Maciejczyk M, Dymicka-Piekarska V, Żendzian-Piotrowska M, Zalewska A. Oxidative imbalance as a co-player in jaw functional limitations and biopsychosocial profile in patients with temporomandibular disorder-Myofascial pain with referral. Frontiers in Neurology. 2025;15:1509845. 3. Gomes AKP, Ximenes TA, Fonseca APR, de Barros Silva PG, Magalhães IA, da Silva Rodrigues AK, et al. Relationship between temporomandibular joint dysfunctions and psychosomatic factors. Revista Eletrônica Acervo Saúde. 2024;24(5):e16019-e. 4. Syroishko M, Kostiuk T. Dysfunction of the temporomandibular joints associated with post-traumatic stress disorders in patients. Reports of Vinnytsia National Medical University. 2023;27(2):253-7. 5. Matos M, Thumati P, Sutter B, Ruiz-Velasco G, Goldberg J, Booth J, et al. Are Temporomandibular Disorders Really Somatic Symptom Disorders? Part II-Joint Vibration Analysis of the Temporomandibular Joint. Advanced Dental Technologies & Techniques. 2021. 6. Patil DJ, Dheer DS, Puri G, Konidena A, Dixit A, Gupta R. Psychological appraisal in temporomandibular disorders: A cross-sectional study. Indian Journal of pain. 2016;30(1):13-8. 7. Canales GDLT, Guarda-Nardini L, Rizzatti-Barbosa CM, Conti PCR, Manfredini D. Distribution of depression, somatization and pain-related impairment in patients with chronic temporomandibular disorders. Journal of Applied Oral Science. 2019;27:e20180210. 8. Urits I, Charipova K, Gress K, Schaaf AL, Gupta S, Kiernan HC, et al. Treatment and management of myofascial pain syndrome. Best Practice & Research Clinical Anaesthesiology. 2020;34(3):427-48. 9. Cao Q-W, Peng B-G, Wang L, Huang Y-Q, Jia D-L, Jiang H, et al. Expert consensus on the diagnosis and treatment of myofascial pai | ||
| 36902775 |
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jan 2026-Dec2026
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| ID | Term |
|---|---|
| D013705 | Temporomandibular Joint Disorders |
| D001008 | Anxiety Disorders |
| D003863 | Depression |
| ID | Term |
|---|---|
| D017271 | Craniomandibular Disorders |
| D008336 | Mandibular Diseases |
| D007571 | Jaw Diseases |
| D009140 | Musculoskeletal Diseases |
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| ID | Term |
|---|---|
| D044169 | Receptors, Calcium-Sensing |
| ID | Term |
|---|---|
| D043562 | Receptors, G-Protein-Coupled |
| D011956 | Receptors, Cell Surface |
| D008565 | Membrane Proteins |
| D011506 | Proteins |
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| Result |
| Szarejko KD, Golebiewska M, Lukomska-Szymanska M, Kuc J. Stress Experience, Depression and Neck Disability in Patients with Temporomandibular Disorder-Myofascial Pain with Referral. J Clin Med. 2023 Mar 2;12(5):1988. doi: 10.3390/jcm12051988. |
| D007592 |
| Joint Diseases |
| D009135 | Muscular Diseases |
| D009057 | Stomatognathic Diseases |
| D001523 | Mental Disorders |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D000602 |
| Amino Acids, Peptides, and Proteins |