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| Name | Class |
|---|---|
| Fonds National de la Recherche Scientifique | OTHER |
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The leading cause of death is cardiovascular diseases in occidental countries. Of those, atherosclerosis is the major contributor to this burden being notably responsible for strokes and myocardial infarctions. The genesis of atherosclerosis is linked to both lipid accumulation and inflammation in the vascular wall of major arteries. One of the major pathways of inflammation is the TGF-beta axis which is at least partially regulated by the GARP protein. It has been investigated mostly in cancer biology but data in cardiovascular disease is lacking. Thus, the investigators aim to characterize the contribution of this protein by investigating its expression in circulating blood cells from patients with an acute or chronic coronary syndrom. The main cells expressing the GARP protein are the platelets and the T regulating cells which will be the main focus.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acute coronary syndrome | Experimental | This arm includes patients undergoing coronary angiography with a final diagnostic of acute coronary syndrome. The intervention administered is an arterial blood sample from the sheath at the beginning of the examination. |
|
| Chronic coronary syndrome | Experimental | This arm includes patients undergoing coronary angiography with a final diagnostic of chronic coronary syndrome. The intervention administered is an arterial blood sample from the sheath at the beginning of the examination. |
|
| Control | Experimental | This arm includes patients undergoing coronary angiography with a final diagnostic of non significant coronary disease. The intervention administered is an arterial blood sample from the sheath at the beginning of the examination. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Arterial blood sample | Biological | An arterial blood sample will be obtained at the beginning of the coronary angiography by using the arterial sheat in place. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Platelet GARP expression | The platelet GARP expression profile will be assessed and compared between arms using flow cytometry. | Throughout the entire study, approximately during 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Inflammatory profile | The inflammatory cytokines (IL-1, IL-6, TNF,...) profile will be determined by multiplex and compared between arms. | Throughout the entire study, approximately during 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Louis Charki, Medical Degree | Contact | +3224362014 | louis.charki@uclouvain.be |
| Name | Affiliation | Role |
|---|---|---|
| Christophe Beauloye, Medical Degree | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cliniques Universitaires Saint-Luc | Brussels | 1200 | Belgium |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| D058226 | Plaque, Atherosclerotic |
| D050197 | Atherosclerosis |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |