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The goal of this clinical trial is to see which type of strengthening exercise with a tight band (blood flow restriction) helps people recover better after ACL reconstruction. The study includes adults after ACL surgery who are doing physiotherapy to rebuild thigh muscle strength and knee function.
The main questions are:
Researchers will compare a heavy-exercise program plus blood flow restriction to a light-exercise program plus blood flow restriction to see which gives better strength and functional improvements.
Participants will:
This clinical trial is testing two different ways of doing strength training with a tight leg cuff (blood flow restriction) during rehabilitation after ACL reconstruction. The aim is to find out which program helps people rebuild thigh muscle strength and knee function more effectively, while still keeping the knee joint safe after surgery.
Study purpose and questions After ACL reconstruction, many people lose muscle size and strength in the front of the thigh, which can slow down recovery and delay return to sport or full activity. Blood flow restriction training allows people to train with lighter weights but still gain strength and muscle, which may be useful when heavy loads are not yet safe.
The main questions are:
What happens in the study Participants will be randomly assigned to one of two groups so that each person has an equal chance of being in either group.
Both groups will:
The physiotherapist will adjust the load (heavy or light), cuff pressure, and number of sets and repetitions according to a fixed protocol so that each participant trains safely and progressively over time.
Measurements and outcomes
Participants will be tested at the start of the study and at follow-up visits (for example, after several weeks and at the end of the program). The main outcome is peak quadriceps strength measured on an isokinetic dynamometer. Other outcomes may include:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ACL Reconstruction Population | Active Comparator |
| |
| Healthy Population | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High Load Isokinetic Training with Blood Flow Restriction | Other | High Load strength training that was administered through the use of an isokinetic device, and not conventional strength training equipment, combined with blood flow restriction. |
| Measure | Description | Time Frame |
|---|---|---|
| Muscle Strength | Muscle strength will be measured using Biodex System 4 Pro for concentric quadriceps and hamstring strength at 60°/s and eccentric quadriceps at 60°/s. Recorded parameters: peak torque(Nm/kg), total work(J), and average power(W). | Outcome measures will be measured at baseline(week 0), mid-intervention(week 3) and post-intervention(week 6) |
| Muscle Girth | Muscle girth will be measured by measuring the mid-thigh circumference using an inch tape at 15cm above the superior border of the patella. The mean of two readings will be recorded | Outcome measures will be measured at baseline(week 0), mid-intervention(week 3) and post-intervention(week 6) |
| Measure | Description | Time Frame |
|---|---|---|
| Pain Reduction | Pain will be evaluated using the Numeric Pain Rating Scale(0-10). This refers to the pain the patient experiences in their operated knee and will observe how it changes with administration of the intervention(s). Scale: 0-10 Minimum value: 0 Maximum value: 10 Higher is worse(more pain). Lower is better(less pain) | Outcome measures will be measured at baseline(week 0), mid-intervention(week 3) and post-intervention(week 6) |
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Inclusion Criteria:
For ACLR group:
•Isolated unilateral ACL reconstruction 8-16 weeks post-surgery with medical clearance for moderate to high resistance training.
For control group(healthy population):
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Osman Z Khan, Bachelors of Physiotherapy | Contact | +971563292389 | osman.thekhan@gmail.com |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20890972 | Background | McNair PJ, Colvin M, Reid D. Predicting maximal strength of quadriceps from submaximal performance in individuals with knee joint osteoarthritis. Arthritis Care Res (Hoboken). 2011 Feb;63(2):216-22. doi: 10.1002/acr.20368. | |
| 36158072 | Background | de Deus Passos M, da Rocha AF. Evaluation of infrared thermography with a portable camera as a diagnostic tool for peripheral arterial disease of the lower limbs compared with color Doppler ultrasonography. Arch Med Sci Atheroscler Dis. 2022 Aug 8;7:e66-e72. doi: 10.5114/amsad/150716. eCollection 2022. |
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| ID | Term |
|---|---|
| D000090003 | Blood Flow Restriction Therapy |
| ID | Term |
|---|---|
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
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|
| Low Load Isokinetic Training with Blood Flow Restriction | Other | Low Load strength training that was administered through the use of an isokinetic device, and not conventional strength training equipment, combined with blood flow restriction. |
|
|
| Blood Flow | The blood flow to the affected knee will be assessed by using infrared thermography(IRT) using standardized imaging protocols(room temperature 20-24°C, 40-60% humidity). | Outcome measures will be measured at baseline(week 0), mid-intervention(week 3) and post-intervention(week 6) |
| Tolerability and Perception of the Intervention(s) | This will be recorded using a Likert-type questionnaire focusing on comfort, tightness, and willingness to repeat the intervention. Minimum value: 0 Maximum value: 10 Higher scores mean a better outcome. Lower scores mean a worse outcome. | Outcome measures will be measured at baseline(week 0), mid-intervention(week 3) and post-intervention(week 6) |
| 30687515 | Background | Corte AC, Pedrinelli A, Marttos A, Souza IFG, Grava J, Jose Hernandez A. Infrared thermography study as a complementary method of screening and prevention of muscle injuries: pilot study. BMJ Open Sport Exerc Med. 2019 Jan 3;5(1):e000431. doi: 10.1136/bmjsem-2018-000431. eCollection 2019. |
| 29731662 | Background | Alghadir AH, Anwer S, Iqbal A, Iqbal ZA. Test-retest reliability, validity, and minimum detectable change of visual analog, numerical rating, and verbal rating scales for measurement of osteoarthritic knee pain. J Pain Res. 2018 Apr 26;11:851-856. doi: 10.2147/JPR.S158847. eCollection 2018. |
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| 38889851 | Background | Gopinatth V, Garcia JR, Reid IK, Knapik DM, Verma NN, Chahla J. Blood Flow Restriction Enhances Recovery After Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Arthroscopy. 2025 Apr;41(4):1048-1060. doi: 10.1016/j.arthro.2024.05.032. Epub 2024 Jun 16. |
| 39678440 | Background | Lin Q, Zhang Y, Qin J, Wu F. Effects of Low-Load Blood Flow Restriction Training on Muscle Volume After Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis. Orthop J Sports Med. 2024 Dec 13;12(12):23259671241301731. doi: 10.1177/23259671241301731. eCollection 2024 Dec. |
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| 35391871 | Background | Koc BB, Truyens A, Heymans MJLF, Jansen EJP, Schotanus MGM. Effect of Low-Load Blood Flow Restriction Training After Anterior Cruciate Ligament Reconstruction: A Systematic Review. Int J Sports Phys Ther. 2022 Apr 1;17(3):334-346. doi: 10.26603/001c.33151. eCollection 2022. |
| 40904716 | Background | Norte GE, Murray AM, Rush JL, Sherman DA, Glaviano NR. Hamstrings Volumetric Adaptations to a Four-Week Nordic Hamstring Exercise Protocol in Individuals with ACL Reconstruction: A Preliminary Case Series. Int J Sports Phys Ther. 2025 Sep 2;20(9):1377-1387. doi: 10.26603/001c.143149. eCollection 2025. |
| 40342351 | Background | Mengis N, Hoher J, Ellermann A, Eberle C, Hartner C, Keller M, Rippke JN, Sprenger N, Stein T, Stoffels T, Egloff C, Niederer D. A Guideline for Validated Return-to-Sport Testing in Everyday Clinical Practice: A Focused Review on the Validity, Reliability, and Feasibility of Tests Estimating the Risk of Reinjury After ACL Reconstruction. Orthop J Sports Med. 2025 May 5;13(5):23259671251317208. doi: 10.1177/23259671251317208. eCollection 2025 May. |
| 17391820 | Background | Hiemstra LA, Webber S, MacDonald PB, Kriellaars DJ. Contralateral limb strength deficits after anterior cruciate ligament reconstruction using a hamstring tendon graft. Clin Biomech (Bristol). 2007 Jun;22(5):543-50. doi: 10.1016/j.clinbiomech.2007.01.009. Epub 2007 Mar 27. |
| Background | Kuenze C, Hart JM. Quadriceps strength thresholds and patient-reported function after anterior cruciate ligament reconstruction: a systematic review. J Sport Rehabil. 2023 Jun 1;32(5):458-468. doi: 10.1123/jsr.2022-0362 |
| 35391858 | Background | Schwery NA, Kiely MT, Larson CM, Wulf CA, Heikes CS, Hess RW, Giveans MR, Solie BS, Doney CP. Quadriceps Strength following Anterior Cruciate Ligament Reconstruction: Normative Values based on Sex, Graft Type and Meniscal Status at 3, 6 & 9 Months. Int J Sports Phys Ther. 2022 Apr 1;17(3):434-444. doi: 10.26603/001c.32378. eCollection 2022. |
| Background | Liao LR, Ng GYF, Jones AY, Lee LK, Leung HK, Ng SSM. Predicting maximal strength of quadriceps from submaximal performance in individuals with knee joint osteoarthritis. J Orthop Sports Phys Ther. 2015;45(5):408-414 |
| 35360229 | Background | Nascimento DDC, Rolnick N, Neto IVS, Severin R, Beal FLR. A Useful Blood Flow Restriction Training Risk Stratification for Exercise and Rehabilitation. Front Physiol. 2022 Mar 11;13:808622. doi: 10.3389/fphys.2022.808622. eCollection 2022. |
| Background | Welsh JJ, Robinson DM, Dankel SJ. A systematic review examining blood flow restriction in combination with isokinetic resistance exercise. J Trainology. 2024;13(1):3-11 |
| 31288213 | Background | Hughes L, Patterson SD, Haddad F, Rosenblatt B, Gissane C, McCarthy D, Clarke T, Ferris G, Dawes J, Paton B. Examination of the comfort and pain experienced with blood flow restriction training during post-surgery rehabilitation of anterior cruciate ligament reconstruction patients: A UK National Health Service trial. Phys Ther Sport. 2019 Sep;39:90-98. doi: 10.1016/j.ptsp.2019.06.014. Epub 2019 Jul 2. |
| 36188864 | Background | Rolnick N, Kimbrell K, Cerqueira MS, Weatherford B, Brandner C. Perceived Barriers to Blood Flow Restriction Training. Front Rehabil Sci. 2021 Jul 8;2:697082. doi: 10.3389/fresc.2021.697082. eCollection 2021. |
| Background | Farooq U, Cheema MY, Imran M, Gulzar M. Acute and chronic blood flow restriction resistance training: mechanisms and applications in sports. J Exerc Sci Fit. 2025;23(2):279-288 |
| Background | Büyüklüoğlu G, Akinoğlu B, Günaydin H, Küçük İ, Örsçelik A, Kocahan T. Isokinetic exercise combined with blood flow restriction (BFR) may produce a greater change in the angle of peak torque. Med Sport. 2025;78(1):18-22 |
| Background | Kubosch EJ, Izadi M, Wawrzyniak N, Hedtmann K, Pässler V, Rolvien T, von der Heide D, Lutter C, Fehér D, Engelhardt M. Blood flow restriction training for hamstring muscle strength after anterior cruciate ligament reconstruction: a randomized controlled trial. Knee. 2024 Aug;41:2444-2452 |
| 40870422 | Background | Kwon S, Bae KC, Yon CJ, Kim DH. Current Narrative Review-Application of Blood Flow Restriction Exercise in Clinical Knee Problems. Medicina (Kaunas). 2025 Jul 30;61(8):1377. doi: 10.3390/medicina61081377. |
| 40671707 | Background | Su C, Zhang Z, Liang B, Zhou S, Long X. Effects of blood flow restriction combined with high-load training on muscle strength and sports performance in athletes: a systematic review and meta-analysis. Front Physiol. 2025 Jul 2;16:1603568. doi: 10.3389/fphys.2025.1603568. eCollection 2025. |
| 40452197 | Background | Piskin NE, Aktug ZB, Kara M, Yavuz G, Ozturk GT, Ibis S, Aka H. The Effect of Blood Flow Restriction Training on Isokinetic Strength Muscle Thickness and Athletic Performance. J Musculoskelet Neuronal Interact. 2025 Jun 1;25(2):208-218. doi: 10.22540/JMNI-25-208. |
| 37693006 | Background | Chang H, Yan J, Lu G, Chen B, Zhang J. Muscle strength adaptation between high-load resistance training versus low-load blood flow restriction training with different cuff pressure characteristics: a systematic review and meta-analysis. Front Physiol. 2023 Aug 25;14:1244292. doi: 10.3389/fphys.2023.1244292. eCollection 2023. |
| 38591459 | Background | Colombo V, Valencic T, Steiner K, Skarabot J, Folland J, O'Sullivan O, Kluzek S. Comparison of Blood Flow Restriction Interventions to Standard Rehabilitation After an Anterior Cruciate Ligament Injury: A Systematic Review. Am J Sports Med. 2024 Dec;52(14):3641-3650. doi: 10.1177/03635465241232002. Epub 2024 Apr 9. |
| D005791 |
| Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |