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The aim of this study is to evaluate the relationship between the severity of Pemphigus Vulgaris (a chronic autoimmune skin disease) and periodontal (gum) health. Researchers will assess disease activity using the Oral Disease Severity Score (ODSS) for mouth lesions and measure serum Desmoglein 1 and 3 levels through blood tests. These findings will be compared with clinical gum measurements, such as pocket depth and attachment levels. The study intends to determine how the clinical and biochemical severity of Pemphigus Vulgaris impacts periodontal tissues and overall oral health.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pemphigus Vulgaris Group | A comprehensive oral examination including ODSS scoring and periodontal measurements (PPD, CAL, PI, GI). Additionally, serum Desmoglein 1 and 3 levels will be retrieved from the patients' medical records for biochemical correlation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Clinical Periodontal and Oral Evaluation | Other | "Participants will undergo a comprehensive oral examination. The severity of oral mucosal involvement will be recorded using the Oral Disease Severity Score (ODSS). Clinical periodontal parameters, including Probing Pocket Depth (PPD) and Clinical Attachment Level (CAL), will be measured at six sites per tooth using a periodontal probe. Additionally, current serum Desmoglein 1 and 3 levels will be retrieved from the patients' medical records for clinical correlation." |
| Measure | Description | Time Frame |
|---|---|---|
| Oral Disease Severity Score (ODSS) | A clinical scoring system used to assess the severity of oral mucosal involvement in patients with Pemphigus Vulgaris. It evaluates the site and extent of lesions in the oral cavity. | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Serum Desmoglein 1 and 3 Levels | Anti-desmoglein 1 and anti-desmoglein 3 autoantibody titers as recorded in the patients' medical laboratory results. Values are measured in Relative Units per milliliter (RU/mL). | Baseline |
| Clinical Attachment Level (CAL) |
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Inclusion Criteria:
Exclusion Criteria:
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The study population consists of adult patients diagnosed with Pemphigus Vulgaris who are receiving treatment or follow-up at the dermatology clinic.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Bilkan KARA, Dr. | Contact | +905383781679 | bilkankara@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Nuriye Işıl Saygun, Professor | University of Health Sciences, Gulhane Faculty of Dentistry, Department of Periodontology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Health Sciences, Gulhane Faculty of Dentistry, Department of Periodontology | Recruiting | Ankara | 06010 | Turkey (Türkiye) |
To protect participant privacy and maintain confidentiality, there are no plans to share individual participant data.
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| ID | Term |
|---|---|
| D010392 | Pemphigus |
| D010510 | Periodontal Diseases |
| D010518 | Periodontitis |
| ID | Term |
|---|---|
| D012872 | Skin Diseases, Vesiculobullous |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
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| ID | Term |
|---|---|
| D003945 | Diagnosis, Oral |
| ID | Term |
|---|---|
| D003813 | Dentistry |
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Measurement of the distance from the cemento-enamel junction to the base of the periodontal pocket in millimeters. Higher values indicate greater attachment loss. |
| Baseline |
| Probing Pocket Depth (PPD) | Measurement of the distance from the gingival margin to the base of the periodontal pocket in millimeters using a periodontal probe. | Baseline |
| Plaque Index (PI) | An index used to assess the thickness of plaque at the gingival margin. It evaluates oral hygiene status on a scale from 0 to 3 for each tooth surface, measured according to the criteria of Silness and Löe. | Baseline |
| Gingival Index (GI) | A clinical index used to assess the severity of gingival inflammation and bleeding tendency. It evaluates the color, consistency, and bleeding of the gums on a scale from 0 to 3, measured according to the criteria of Silness and Löe. | Baseline |
| D007154 | Immune System Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |