Periodontal Status and Disease Severity in Pemphigus Vulgaris Patients

Clinical Investigation of the Relationship Between Disease Severity and Periodontal Status in Patients With Pemphigus Vulgaris

The aim of this study is to evaluate the relationship between the severity of Pemphigus Vulgaris (a chronic autoimmune skin disease) and periodontal (gum) health. Researchers will assess disease activity using the Oral Disease Severity Score (ODSS) for mouth lesions and measure serum Desmoglein 1 and 3 levels through blood tests. These findings will be compared with clinical gum measurements, such as pocket depth and attachment levels. The study intends to determine how the clinical and biochemical severity of Pemphigus Vulgaris impacts periodontal tissues and overall oral health.

Inclusion Criteria:

• Patients aged 18 years and older.
• Clinically and histopathologically confirmed diagnosis of Pemphigus Vulgaris.
• Presence of at least 10 natural teeth.
• Willingness to participate and signed informed consent.

Exclusion Criteria:

• Pregnancy or lactation.
• Use of systemic antibiotics or anti-inflammatory drugs within the last 3 months.
• Periodontal treatment received within the last 6 months.