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| Name | Class |
|---|---|
| Chongqing Renpin ENT. Hospital, China | UNKNOWN |
| Nanjing Renpin ENT. Hospital, China | UNKNOWN |
| Chengdu Renpin ENT. Hospital, China | UNKNOWN |
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Tinnitus affects an estimated 10-15% of the global population and can substantially impair quality of life, yet clinically actionable approaches for subtype identification and risk stratification remain limited. This multicenter, cross-sectional observational study will use de-identified electronic health record (EHR) data from three otolaryngology specialty hospitals in China to address these gaps. All extracted data will be de-identified with direct identifiers removed, and privacy safeguards will be implemented in accordance with institutional policies and applicable regulations to protect patient confidentiality.
Using a prespecified, clinically informed framework, we will classify tinnitus into relevant subtypes, including somatosensory tinnitus, acute vs. chronic tinnitus, pulsatile tinnitus, and sudden hearing loss-related tinnitus. We will first describe the distribution of these subtypes and characterize their demographic, clinical, and laboratory profiles. We will then evaluate associations between candidate risk factors and subtype membership using multivariable analyses to quantify adjusted effects. Finally, we will develop and validate multivariable prediction models using both conventional statistical approaches and machine learning methods to support tinnitus subtype classification. Model performance will be assessed using discrimination, calibration, and clinical utility metrics. By integrating routine clinical data with biomarker information captured in real-world care, this study aims to provide evidence-based tools to improve tinnitus subtype diagnosis and enable more personalized clinical assessment.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Observational group | Other | This is a multicenter, cross-sectional observational study using existing electronic health record data collected during routine clinical care.We will use retrospectively extracted electronic health record data from multiple otolaryngology specialty hospitals to identify risk factors and develop predictive models for tinnitus subtypes at a single index time point. |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Patients in Each Tinnitus Subtype | The number of participants classified into each predefined tinnitus subtype based on an integrated diagnosis clinical classification framework. | baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Adjusted odds ratios of risk factors associated with each tinnitus subtype | Multivariable logistic regression-derived odds ratios quantifying the independent association between risk factors and specific tinnitus subtypes. | baseline |
| Accuracy of prediction models for identifying tinnitus subtype classification |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with any type of tinnitus from three otolaryngology specialty hospitals in China
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| Name | Affiliation | Role |
|---|---|---|
| Hongsheng Tan, Dr | Shanghai Jiao Tong University School of Medicne | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chongqing Renpin ENT Hospital | Chongqing | China |
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| ID | Term |
|---|---|
| D014012 | Tinnitus |
| ID | Term |
|---|---|
| D006311 | Hearing Disorders |
| D004427 | Ear Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D012678 | Sensation Disorders |
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This is an observational study and no samples will be collected.
The diagnostic performance of a multimodal classification model for identifying tinnitus subtype. The model integrates clinical characteristics, laboratory parameters, and computed tomography imaging features. Tinnitus subtype, determined by physician medical diagnosis, serves as the reference standard. Model performance will be quantified using the area under the receiver operating characteristic curve (AUC). The unit of measure is Area under the ROC curve (AUC). |
| baseline |
| D009461 |
| Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |