Wpływ Podawanego Doustnie Ekstraktu z Aronii, Jagody Kamczackiej Oraz Czarnej Jagody na Stan narządu Wzroku.
Wpływ Podawanego Doustnie Ekstraktu z Aronii, Jagody Kamczackiej Oraz Czarnej Jagody na Stan narządu Wzroku.
This study evaluated whether a standardized berry-extract dietary supplement (AKB; Aronia melanocarpa, Lonicera caerulea, Vaccinium myrtillus) improves visual function in adults with presbyopia. In a randomized, double-blind, placebo-controlled two-period crossover design, participants received AKB 400 mg twice daily and placebo for 6 weeks each, separated by a 5-week washout. Visual function and retinal/neuronal measures were assessed with contrast sensitivity testing, visual fields, VEP, and OCT/AngioOCT. Serum biomarkers related to lens and retinal physiology were also measured.
Participants were randomized to one of two sequences (AKB→placebo or placebo→AKB). Each treatment period lasted 6 weeks, separated by a 5-week washout. Ophthalmological assessments were performed at baseline and during the final week of each treatment period. The primary analysis compared within-participant changes after AKB versus placebo.
Inclusion Criteria:
Age ≥ 50 years.
Clinical diagnosis of presbyopia.
Best-corrected visual acuity (BCVA) ≥ 20/40.
Spherical refraction between -3.0 and +3.0 diopters (D).
Cylinder correction ≤ ±3.0 D.
Exclusion Criteria:
Age < 50 years.
History of ocular surgery within 12 months prior to enrollment.
Presence of ocular diseases/conditions that may affect outcomes, including:
Macular degeneration
Diabetic retinopathy
Retinal vein occlusion
Glaucoma
Other significant acquired or hereditary eye conditions
Neurological disorders affecting visual fields.
Refractive error outside eligibility limits:
Spherical refraction < -3.0 D or > +3.0 D
Cylinder correction > ±3.0 D
Systemic conditions that may influence optic nerve head perfusion, including:
Hypotension
Severe circulatory failure
Vascular endothelial disorders
Gastrointestinal conditions, including:
Hyperacidity
Peptic ulcer disease