Evaluatıon of TREM-1, MMP-8 and TIMP-1 Levels in Perı-Imp... | NCT07379892

Studies
Evaluatıon of TREM-1, MMP-8 and TIMP-1 Levels in Perı-Implant Crevicular Fluıd of Perı-Implanted Indıvıduals

NCT07379892

Sponsor

Aydin Adnan Menderes University

Status

Completed

Last Update Posted

Feb 9, 2026Actual

Enrollment

54Actual

Phase

Not provided

Conditions

Periimplantitis

Interventions

Collection of PICF samples

Countries

Turkey (Türkiye)

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

Feb 2026

Overall Recruitment Status or Expanded Access Status

Completed

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Jun 1, 2023Actual

Primary Completion Date

Dec 15, 2023Actual

Completion Date

May 20, 2024Actual

First Submitted Date

Jan 25, 2026

First Submission Date that Met QC Criteria

Jan 25, 2026

First Posted Date

Feb 2, 2026Actual

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Feb 5, 2026

Last Update Posted Date

Feb 9, 2026Actual

Sponsor/Collaborators Module

Responsible Party, by Official Title

Veli Özgen Öztürk, Principal Investigator, Aydin Adnan Menderes UniversityPrincipal Investigator

Lead Sponsor

Aydin Adnan Menderes UniversityOTHER

Collaborators

Not provided

Oversight Module

Has Data Monitoring Committee (DMC)

Is FDA Regulated Drug

Is FDA Regulated Device

Is Unapproved Device

Not provided

Pediatric Postmarket Surveillance of a Device Product

Not provided

Product Exported from US

Not provided

FDAAA801 Violation

Not provided

Description Module

Brief Summary

The aim of this study was to evaluate the relationship between Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1), Matrix Metalloproteinases-8 (MMP-8) and Tissue Inhibitors of Metalloproteinases-1 (TIMP-1) levels in peri-implant crevicular fluid (PICF) in peri-implantitis patients.

Detailed Description

The aim of this study was to evaluate the relationship between TREM-1, MMP-8 and TIMP-1 levels in peri-implant crevicular fluid (PICF) in patients with peri-implantitis, and the correlation of these markers with clinical periodontal parameters.

Design Module

Study Type

Observational

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Yes

Target Follow-Up Duration

12 Months

Phases

Not provided

Interventional Study Design

Allocation

Not provided

Intervention Model

Biospecimen

No data available

No data is available for this block.

Enrollment

54Actual

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Peri-implantitis		Peri-implantitis is defined as bleeding on probing, suppuration, increased probing depth, clinical attachment loss, and radiographic bone loss	Other: Collection of PICF samples
Peri-implant Health		Peri-implant health is characterized by the absence of bleeding on probing, erythema, swelling, and suppuration in the peri-implant region	Other: Collection of PICF samples

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Collection of PICF samples	Other	TREM-1, MMP-8 and TIPM-1 levels reseach in PICF samples	Peri-implant Health Peri-implantitis

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
TREM-1, MMP-8 and TIMP-1 levels in PICF samples	TREM-1, MMP-8, and TIMP-1 levels in PICF samples were measured by ELISA method	1 month

Secondary Outcomes

Not provided

Other Outcomes

Not provided

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

Systemically healthy
Pregnancy or lactation

Exclusion Criteria:

osteoporosis
rheumatoid arthritis
autoimmune disease
diabetes

Accepts Healthy Volunteers

Yes

Sex

All

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

18 Years

Maximum Age

70 Years

Standard Ages

AdultOlder Adult

Study Population

All patients had at least one implant, and this implant had been in place for at least one year since the implant-supported prosthesis was made.

Sampling Method

Non-Probability Sample

Contacts/Locations Module

Central Contacts

Not provided

Overall Officials

Not provided

Locations

Facility	Status	City	State	ZIP	Country	Contacts
Aydın Adnan Menderes University		Aydin			Turkey (Türkiye)

IPD Sharing Statement Module

Plan to Share IPD

Undecided

Description

Not provided

Types

Not provided

Time Frame

Not provided

Access Criteria

Not provided

URL

Not provided

Condition Browse Module

MeSH Terms

ID	Term
D057873	Peri-Implantitis

Ancestor Terms

ID	Term
D010510	Periodontal Diseases
D009059	Mouth Diseases
D009057	Stomatognathic Diseases

Browse Leaves

Not provided

Browse Branches

Not provided