This study will measure immune persistence of the NmCV-5 more than 5 years after a single dose vaccination in participants 2-29 years of age in Mali and The Gambia.

This non-interventional long-term follow-up study will involve one telephonic contact in all 1800 former participants from study ACYWX-03 followed by one visit beyond five years after vaccination in a subset of 450 participants. This subset will be randomly selected to participate in a follow-on immune persistence evaluation. To document the duration of the immune response and any requirement of booster dose in the target population, this study is intended to explore antibody persistence.

Inclusion Criteria:

• Written informed consent and assent (if applicable)

Exclusion Criteria:

• Current or previous, confirmed disease caused by Neisseria meningitidis at any given time since meningococcal vaccination
• Any condition or criteria that in the opinion of the investigator might compromise the well-being of the participant or the compliance with study procedures or interfere with the outcome of the study

Participants from the previous study ACYWX-03 conducted at the Gambia and Mali