Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The aim of this study is to compare the efficacy of magnesium sulphate, ondansetron, and dexmedetomidine in managing post-spinal anesthesia shivering. The primary aim is the time to cessation of shivering after drug administration, while secondary aim include hemodynamic parameters (heart rate, blood pressure, SpOâ‚‚ ) and the recurrence of shivering
This is a randomized double blinded study including patients undergoing surgery under spinal anesthesia. Patients will be randomly allocated into three groups to receive magnesium sulphate, ondansetron, or dexmedetomidine for the treatment of post-spinal anesthesia shivering. The time to cessation of shivering, hemodynamic parameters, and recurrence of shivering will be recorded.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mg sulphate group | Experimental | 50 mg/kg magnesium sulphate diluted in 100 mL of normal saline. |
|
| dexmedetomidine group | Experimental |
| |
| ondansetron group | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidin | Drug | •Group D (Dexmedetomidine Group): 0.5 µg/kg dexmedetomidine diluted in 100 mL of normal saline. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Time to cessation of shivering after drug administration. | Grade 0: No shivering.
| 6 hours |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Aya Mohammed Aboelwafa, Resident of anesthesia | Contact | 01095848062 | 01002181828 | aya_muhammad_post@med.sohag.edu.eg |
| Ahmed Elsaied Abd Elrahman, Professor | Contact | 01118011611 | 01095848062 | elsaiedsoon@gmail.com |
Not provided
Not provided
A decision regarding sharing individual participant data has not yet been made. This will depend on future agreements, ethical approvals, and data governance policies.
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| D008278 | Magnesium Sulfate |
| D017294 | Ondansetron |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Mg (magnesium sulfate) | Drug | 50 mg/kg magnesium sulphate diluted in 100 mL of normal saline. |
|
| Ondansetron 8 mg | Drug | 8 mg ondansetron diluted in 100 mL of normal saline. |
|
| D017616 |
| Magnesium Compounds |
| D007287 | Inorganic Chemicals |
| D013431 | Sulfates |
| D013464 | Sulfuric Acids |
| D013456 | Sulfur Acids |
| D013457 | Sulfur Compounds |
| D002227 | Carbazoles |
| D007211 | Indoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006575 | Heterocyclic Compounds, 3-Ring |