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The goal of this observational study is to compare predictive equations for continuous positive airway pressure (CPAP) with in-laboratory manual titration in patients with obstructive sleep apnea (OSA).
The main question the study aims to answer is:
Which CPAP predictive equation best predicts the optimal CPAP pressure in OSA patients in Thailand? Participants will undergo an in-laboratory sleep study.
This study is a cross-sectional study involving Thai patients aged 18 years or older with suspected obstructive sleep apnea (OSA). Participants will undergo an in-laboratory sleep study. During the study, sleep technicians will use CPAP predictive equations to estimate the optimal CPAP pressure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Obstructive sleep apnea (OSA) | Patients aged 18 years or older with OSA |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sleep test | Diagnostic Test | Type 1 polysomnography will be performed in the Sleep Center of Thammasat (SCENT). |
|
| Measure | Description | Time Frame |
|---|---|---|
| Accuracy of CPAP equations in predicting the optimal pressure in OSA patients | Sensitivity and specificity (%) of CPAP equations in predicting the optimal pressure in OSA patients | At baseline |
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Inclusion Criteria:
Exclusion Criteria:
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Patients aged 18 years or older with suspected OSA
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Narongkorn Saiphoklang, MD | Contact | +6629269794 | M_narongkorn@hotmail.com | |
| Apiwat Pugongchai, MSc | Contact | +669269142 | pu.apiwat@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Narongkorn Saiphoklang | Thammasat University Faculty of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine, Thammasat University | Recruiting | Pathum Thani | 12120 | Thailand |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 12833183 | Result | Lin IF, Chuang ML, Liao YF, Chen NH, Li HY. Predicting effective continuous positive airway pressure in Taiwanese patients with obstructive sleep apnea syndrome. J Formos Med Assoc. 2003 Apr;102(4):215-21. | |
| 18797117 | Result | Chuang ML, Lin IF, Vintch JR, Liao YF. Predicting continuous positive airway pressure from a modified split-night protocol in moderate to severe obstructive sleep apnea-hypopnea syndrome. Intern Med. 2008;47(18):1585-92. doi: 10.2169/internalmedicine.47.1107. Epub 2008 Sep 16. |
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IPD and documents will be available for sharing immediately after publication for a period of 2 years.
IPD and documents will be available for sharing immediately after publication for a period of 2 years.
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| Predictive equations of continuous positive airway pressure (CPAP) | Other | CPAP predictive equations will be selected based on evidence from reliable studies. |
|
| Narongkorn Saiphoklang | Recruiting | Pathum Thani | 12120 | Thailand |
|
| 23145885 | Result | Luo J, Xiao S, Qiu Z, Song N, Luo Y. Comparison of manual versus automatic continuous positive airway pressure titration and the development of a predictive equation for therapeutic continuous positive airway pressure in Chinese patients with obstructive sleep apnoea. Respirology. 2013 Apr;18(3):528-33. doi: 10.1111/resp.12014. |
| 24731756 | Result | Wu MF, Hsu JY, Huang WC, Shen GH, Wang JM, Wen CY, Chang KM. Should sleep laboratories have their own predictive formulas for continuous positive airway pressure for patients with obstructive sleep apnea syndrome? J Chin Med Assoc. 2014 Jun;77(6):283-9. doi: 10.1016/j.jcma.2014.02.015. Epub 2014 Apr 14. |
| 39716408 | Result | Pang F, Deng W, Huang J, Guo Y, Lin M, Zhang X, Liu J. Prediction of Optimal Positive Airway Pressure in Chinese Patients With Obstructive Sleep Apnea. Clin Respir J. 2024 Dec;18(12):e70047. doi: 10.1111/crj.70047. |
| 21217962 | Result | Choi JH, Kim EJ, Kim KW, Choi J, Kwon SY, Lee HM, Kim TH, Lee SH, Shin C, Lee SH. Optimal continuous positive airway pressure level in korean patients with obstructive sleep apnea syndrome. Clin Exp Otorhinolaryngol. 2010 Dec;3(4):207-11. doi: 10.3342/ceo.2010.3.4.207. Epub 2010 Dec 22. |
| 23051618 | Result | Lee GH, Kim MJ, Lee EM, Kim CS, Lee SA. Prediction of optimal CPAP pressure and validation of an equation for Asian patients with obstructive sleep apnea. Respir Care. 2013 May;58(5):810-5. doi: 10.4187/respcare.01860. |
| 32883901 | Result | Sarma L, Putti N, Alias K, Chilana M. Determination of equation for estimating continuous positive airway pressure in patients with obstructive sleep apnea for the Indian population. Lung India. 2020 Sep-Oct;37(5):411-414. doi: 10.4103/lungindia.lungindia_322_19. |
| 36968331 | Result | Bamagoos AA, Alshaynawi SA, Gari AS, Badawi AM, Alhiniah MH, Alshahrani AA, Rajab RR, Bahaj RK, Alhejaili F, Wali SO. Optimal positive airway pressure requirement and polysomnography indices of obstructive sleep apnea severity in the Saudi population. Ann Thorac Med. 2023 Jan-Mar;18(1):31-38. doi: 10.4103/atm.atm_183_22. Epub 2023 Jan 25. |
| 27878543 | Result | Ebben MR, Narizhnaya M, Krieger AC. A new predictive model for continuous positive airway pressure in the treatment of obstructive sleep apnea. Sleep Breath. 2017 May;21(2):435-442. doi: 10.1007/s11325-016-1436-7. Epub 2016 Nov 22. |
| 34230571 | Result | Saiphoklang N, Leelasittikul K, Pugongchai A. Prediction of optimal continuous positive airway pressure in Thai patients with obstructive sleep apnea. Sci Rep. 2021 Jul 6;11(1):13935. doi: 10.1038/s41598-021-93554-5. |
| ID | Term |
|---|---|
| D020181 | Sleep Apnea, Obstructive |
| ID | Term |
|---|---|
| D012891 | Sleep Apnea Syndromes |
| D001049 | Apnea |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D020919 | Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D017286 | Polysomnography |
| ID | Term |
|---|---|
| D008991 | Monitoring, Physiologic |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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