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The purpose of this study was to compare the sensitivity and specificity of the Geriatric Nutritional Risk Index (GNRI), Mini Nutritional Assessment Scale-Short Form (mNA-SF) and Systemic Immune-Inflammatory Index (SII) values calculated in the preoperative evaluation in patients over 65 years of age who underwent gastrointestinal surgery, in predicting morbidity and mortality in the postoperative period.
It is crucial to evaluate the impact of nutritional status and systemic inflammation markers on postoperative outcomes in geriatric patients undergoing gastrointestinal surgery.
Nutritional status has a decisive impact on the development of morbidity and mortality in geriatric patients. The risk of malnutrition is particularly high in the geriatric patient population undergoing gastrointestinal surgery. Predicting postoperative outcomes in these patient groups is becoming increasingly important. To this end, many different risk scoring systems have been developed.
Low nutritional scores and increased inflammatory responses are associated with high mortality, prolonged hospitalization and intensive care unit stays, and complications. The primary goal of preoperative risk scoring is to predict potential complications before, during, and after surgery, and to minimize risks and mortality by attempting to prevent them.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Geriatric Gastrointestinal Surgery Patients. | This group consists of 200 geriatric patients aged 65 and older who are scheduled to undergo gastrointestinal surgery. Participants are within the ASA 3-4 risk groups and must have a Mini-Mental State Examination (MMSE) score of 21 or higher to be included. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Preoperative Risk Scoring | Other | Patients will be evaluated preoperatively using three distinct scoring systems: the Geriatric Nutritional Risk Index (GNRI), the Mini Nutritional Assessment-Short Form (mNA-SF), and the Systemic Immune-Inflammation Index (SII). These scores are calculated based on serum albumin levels, body weight, a 6-question survey, and laboratory values (platelets, neutrophils, and lymphocytes). |
| Measure | Description | Time Frame |
|---|---|---|
| Systemic Immune-Inflammation Index (SII) | Calculated as (Platelets x Neutrophils) / Lymphocytes from preoperative blood samples.The unit of measure is cells per microliter. | Preoperative (Baseline) |
| Geriatric Nutritional Risk Index (GNRI) as a predictor of postoperative complications | GNRI will be calculated using serum albumin and body weight. Scores will be used to categorize patients' nutritional risk.Units on a scale of 0 to 120, where lower scores indicate higher nutritional risk. | Preoperative (Baseline) |
| Mini Nutritional Assessment-Short Form (mNA-SF) score | A 6-question survey to screen for malnutrition.Measured on a scale of 0 to 14 points, where 0-7 indicates malnourishment. | Preoperative (Baseline) |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative Morbidity | Monitoring of pulmonary (e.g., pneumonia, embolism) and extrapulmonary (e.g., surgical site infection, organ failure, anastomosis leak) complications | Up to 30 days post-surgery |
| Incidence of Delirium |
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Inclusion Criteria:
Age 65 years and older.
ASA (American Society of Anesthesiologists) physical status class 3 or 4.
Mini-Mental State Examination (MMSE) score of 21 or higher
Exclusion Criteria:
Patients with acute infection during the preoperative period.
Patients who received albumin replacement in the preoperative period.
Patients with a Mini-Mental State Examination (MMSE) score below 21.
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Geriatric patients scheduled for gastrointestinal surgery at a single-center tertiary care urban hospital (SBÜ Kartal Dr. Lütfi Kırdar City Hospital).".
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| Name | Affiliation | Role |
|---|---|---|
| Minel N KUTUPOGLU SEZER, MD | University of Health Sciences, Kartal Dr. Lutfi Kirdar City Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kartal Dr. Lutfi Kirdar City Hospital | Istanbul | Kartal | 34890 | Turkey (Türkiye) |
De-identified individual participant data that underlie the results reported in this article (text, tables, figures, and appendices) will be shared.
Beginning 6 months and ending 36 months following article publication.
Researchers who provide a methodologically sound proposal to achieve aims in the approved proposal.
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| Postoperative Morbidite and Mortality Monitoring | Other | Systematic tracking of postoperative outcomes including hospital and ICU stay duration, pulmonary complications (e.g., pneumonia, embolism), extrapulmonary complications (e.g., surgical site infection, organ failure, delirium), and mortality rates at 30, 60, and 90 days. |
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| Delirium Assessment Protocol | Other | Patients will be monitored for delirium preoperatively, on the first postoperative day, and before discharge using the Confusion Assessment Method (CAM/CAM-ICU) and the Richmond Agitation-Sedation Scale (RASS). |
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Assessment of delirium using the Confusion Assessment Method (CAM/CAM-ICU) and Richmond Agitation-Sedation Scale (RASS).
| Preoperative to discharge |
| Length of Hospital and ICU Stay | Recording the number of days spent in the hospital and intensive care unit. | Total duration of hospitalization |
| Postoperative Mortality Rate | Tracking patient survival rates at specified intervals after the operation. | 30, 60, and 90 days post-surgery |