Effects and Safety of Oliceridine in Anesthesia Induction:A Randomised Controlled Trial

Study of Effects and Underlying Mechanisms of Analgesic Drugs on Inflammatory Pathways and Immune Function in Patients With Endometrial Cancer

to investigate whether oliceridine is safe and effective for induction of anesthesia by comparing henodynamic changes before and after endotracheal intubation with sufentanil

Inclusion Criteria:

1. Age 18-65 years;
2. American Society of Anesthesiologists (ASA) physical status I-II;
3. Elective gynecologic laparoscopic surgery;
4. Expected operative time 60-180 minutes;

Exclusion Criteria:

1. Severe cardiovascular instability (e.g., acute decompensated heart failure, acute myocardial infarction, or life-threatening arrhythmia);
2. Uncontrolled hypertension;
3. Severe renal or hepatic dysfunction;
4. Severe mental disorder or psychiatric illness;
5. Known allergy or hypersensitivity to opioids;
6. History of alcohol abuse or opioid addiction;
7. Anticipated difficult airway;
8. Pregnancy or lactation;