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to investigate whether oliceridine is safe and effective for induction of anesthesia by comparing henodynamic changes before and after endotracheal intubation with sufentanil
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| sufentanil | Active Comparator | 0.5μg/kg of sufentanil was used for anesthesia induction |
|
| Oliceridine | Experimental | 0.13mg/kg oliceridine was used for anesthesia induction |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oliceridine | Drug | Oliceridine is diluted to a 1mg/kg injection solution |
| |
| Measure | Description | Time Frame |
|---|---|---|
| blood pressure | baseline, at the moment of intubation, right after intubation, 1 minute、3 minutes, and 5 minutes after intubation | |
| heart beat | baseline, at the moment of intubation, right after intubation, 1 minute、3 minutes, and 5 minutes after intubation |
| Measure | Description | Time Frame |
|---|---|---|
| adverse reactions | from the administration of sufentanil or oliceridine until discharge from the post-anesthesia care unit (PACU) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tangshan Maternal and Child Health Hospital | Tangshan | Hebei | 063000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36538359 | Background | Simons P, van der Schrier R, van Lemmen M, Jansen S, Kuijpers KWK, van Velzen M, Sarton E, Nicklas T, Michalsky C, Demitrack MA, Fossler M, Olofsen E, Niesters M, Dahan A. Respiratory Effects of Biased Ligand Oliceridine in Older Volunteers: A Pharmacokinetic-Pharmacodynamic Comparison with Morphine. Anesthesiology. 2023 Mar 1;138(3):249-263. doi: 10.1097/ALN.0000000000004473. | |
| 34819362 |
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| ID | Term |
|---|---|
| C586842 | ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine |
| D017409 | Sufentanil |
| ID | Term |
|---|---|
| D005283 | Fentanyl |
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Sufentanil |
| Drug |
sufentanil is diluted to a 5μg/ml injection solution |
|
| Background |
| Stahl EL, Schmid CL, Acevedo-Canabal A, Read C, Grim TW, Kennedy NM, Bannister TD, Bohn LM. G protein signaling-biased mu opioid receptor agonists that produce sustained G protein activation are noncompetitive agonists. Proc Natl Acad Sci U S A. 2021 Nov 30;118(48):e2102178118. doi: 10.1073/pnas.2102178118. |
| 40524805 | Background | Yang W, Zhou R, Zhou X, Chen X, Zhou D, Zhang X. Effective Dose of Oliceridine Fumarate Co-Administered with Remimazolam in Suppressing Gastroscope Insertion Responses for Adults. Drug Des Devel Ther. 2025 Jun 10;19:5033-5041. doi: 10.2147/DDDT.S527586. eCollection 2025. |
| 40546662 | Background | Ma B, Li Y, Leng C, Ji A, Zhang N, Tao X, Cao Q, Wang S. A Comparative Evaluation of the Safety and Efficacy of Oliceridine and Sufentanil in Gastrointestinal Endoscopy: A Single-Center, Randomized Controlled Trial. Drug Des Devel Ther. 2025 Jun 17;19:5111-5121. doi: 10.2147/DDDT.S512529. eCollection 2025. |
| 14997083 | Background | Iannuzzi E, Iannuzzi M, Cirillo V, Viola G, Parisi R, Cerulli A, Chiefari M. Peri-intubation cardiovascular response during low dose remifentanil or sufentanil administration in association with propofol TCI. A double blind comparison. Minerva Anestesiol. 2004 Mar;70(3):109-15. |
| 32483139 | Background | Teong CY, Huang CC, Sun FJ. The Haemodynamic Response to Endotracheal Intubation at Different Time of Fentanyl Given During Induction: A Randomised Controlled Trial. Sci Rep. 2020 Jun 1;10(1):8829. doi: 10.1038/s41598-020-65711-9. |