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This study aims to evaluate the diagnostic efficacy and prognostic value of 18F-FAPI PET/CT in lung cancer.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| FAPI-Lung-ca | 18F FAPI PET scans |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 18F-FAPI PET | Diagnostic Test | 1、Patients clinically suspected or confirmed with lung cancer are required to complete conventional imaging examinations (CT/MR or FDG PET) and undergo ¹⁸F-FAPI PET/CT. |
| Measure | Description | Time Frame |
|---|---|---|
| Diagnostic efficacy | Sensitivity, specificity, positive and negative predictive value of 18F-FAPI PET Imaging in lung cancer. | through study completion, an average of 1.5 year |
| Measure | Description | Time Frame |
|---|---|---|
| Standard uptake value (SUV)of tumor | This measure evaluates the association between baseline 18F-FAPI PET parameters (e.g., SUVmax, SUVmean). | through study completion, 3-4 years |
| Metabolic tumor volume (c) and total lesion glycolysis (TLG) of tumor |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Donghe Chen, MD | Contact | 0571-87236432 | chendonghe@zju.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Donghe Chen, MD | Zhejiang University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The First Affiliated Hospital, Zhejiang University School of Medicine | Hangzhou | Zhejiang | 310003 | China |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_ICF | Yes | No | Yes | Study Protocol and Informed Consent Form | Nov 7, 2025 | Jan 19, 2026 | Prot_ICF_000.pdf |
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| ID | Term |
|---|---|
| D008175 | Lung Neoplasms |
| D004194 | Disease |
| ID | Term |
|---|---|
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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This measure evaluates the association between baseline 18F-FAPI PET parameters (MTV in cm3, TLG in cm3*SUV)
| through study completion, 3-4 years |
| Prognostic Value of Baseline 18F-FAPI PET for Progression-Free Survival (PFS) in High-Risk Patients | PFS will be defined as the time from diagnosis to disease progression or relapse, assessed using the Kaplan-Meier method and Cox proportional hazards model.(PFS in months) | through study completion, 3-4 years |
| D008171 |
| Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |