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The primary objective of this study is to describe the prevalence of airway closure during the total support phase of invasive mechanical ventilation in subjects admitted to an intensive care unit (ICU). The secondary objective is to analyze whether there are clinical-demographic and/or ventilatory characteristics associated with the presence of airway closure.
Cross-sectional study. To detect airway closure, the maneuver will be performed at low flow and in case of having an opening pressure greater than 5 cmh20, the electrical impedance tomograph will be placed to record the delay in the change of impedance of each quadrant.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| airway closure | Other | After setting the flow at 5 L/min and positive end-expiratory pressure (PEEP) at 0 cmH2O, the respiratory rate will be transiently decreased to achieve a prolonged expiration of 5-10 seconds to eliminate auto-PEEP. During two breaths, the change in the slope of the pressure-time curve will be observed. Airway Closure be detected as a change in the slope of the pressure-time curve. Airway Opening Pressure value, in cmH2O, will be identified on the pressure-volume curve using the cursor while the mechanical ventilator screen is frozen. Upon completion of this procedure, the ventilator settings will be returned to the patient's initial parameters. |
| Measure | Description | Time Frame |
|---|---|---|
| airway closure | After setting the flow at 5 Litres/minute and positive end-expiratory pressure (PEEP) at 0 cmH2O, the respiratory rate will be transiently decreased to achieve a prolonged expiration of 5-10 seconds to eliminate auto-PEEP. During two breaths, the change in the slope of the pressure-time curve will be observed. Airway Closure be detected as a change in the slope of the pressure-time curve. Airway Opening Pressure value, in cmH2O, will be identified on the pressure-volume curve using the cursor while the mechanical ventilator screen is frozen. Upon completion of this procedure, the ventilator settings will be returned to the patient's initial parameters. | first 72 hours after intubation |
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Inclusion Criteria:
Exclusion Criteria:
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The study population consists of adult patients undergoing mechanical ventilation within the first 72 hours following endotracheal intubation.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Romina B Mattei | Contact | +541140485216 | rominabelenmattei@gmail.com | |
| Maria E Dotta | Contact | +5455722761 | mariaeugeniadotta@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Romina B Mattei | CMPFA Churruca-Visca | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CMPFA Churruca-Visca | Recruiting | Buenos Aires | Buenos Aires | 1437 | Argentina |
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