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The purpose of this clinical study is to perform phosphorus nucleus (31P) and sodium nucleus (23Na) imaging of the liver in patients with primary hepatocellular carcinoma (HCC) and healthy volunteers using the MR 7700 Magnetic Resonance Equipment, in order to explore the manifestations of multinuclear imaging in HCC patients and healthy volunteers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HCC patients | Experimental | HCC patients |
|
| Healthy volunteers | Placebo Comparator | Healthy volunteers |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MR Scanning with Phosphorus nucleus + Sodium nucleus | Device | Using the Magnetic Resonance Equipment to perform phosphorus nucleus (31P) and sodium nucleus (23Na) scanning |
|
| Measure | Description | Time Frame |
|---|---|---|
| Ratio of metabolites (PME/PDE) | By comparing the ratios of metabolites (PME/PDE) in the liver, the effectiveness of 31P magnetic resonance spectroscopy (31P-MRS) was evaluated. Theoretically,the PME/PDE ratio in patients with HCC was higher than that in healthy volunteers. | 14 days (anticipated)] after finishing 31P-MRS scanning |
| Image quality of 23Na-MRI | Image quality will be assessed by Likert score (1-5) | 14 days (anticipated)] after finishing 23Na-MRI scanning |
| Adverse Event | Monitor adverse events and serious adverse events during the study,summarize and analyze the frequency and percentage of all adverse events (including severe adverse events) | From the time the subjects signed the ICF to completion of study visit(1 day). |
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Inclusion Criteria:
1. HCC patient group
2. Healthy control group
Exclusion Criteria:
HCC patient group and healthy control group
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fu Hua Yan | Contact | (+86)13661850380 | yfh11655@rjh.com | |
| Andi Gao | Contact | (+86)13601250646 | Andi.Gao@Philips.com |
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| ID | Term |
|---|---|
| D006528 | Carcinoma, Hepatocellular |
| ID | Term |
|---|---|
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
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| D009369 | Neoplasms |
| D008113 | Liver Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D004066 | Digestive System Diseases |
| D008107 | Liver Diseases |