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| Name | Class |
|---|---|
| Karolinska Institutet | OTHER |
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Patients undergoing allogenic stem cell transplantation are regularly followed up in the outpatient clinic at Karolinska University Hospital. Here, patients are offered participation the fatigue study measuring both fatigue and cognitive impairment systematically by international standard. Meanwhile liquor samples and advanced PET imaging techniques are available for these patients as part of a research project allowing extensive immunological and radio-morphological studies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with fatigue and cognitive dysfunction |
| ||
| Patients without fatigue and cognitive dysfunction |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PET investigation | Radiation | Trial subjects will undergo two advanced PET investigations |
|
| Measure | Description | Time Frame |
|---|---|---|
| To investigate the role of inflammation on synaptic density and glial cell activation as the cause of mental fatigue and cognitive dysfunction in survivors after alloSCT. | Analysis of PET imaging (both descriptive and radiokinetical) in combination with biological markers for neuroinflammation. | 2024-2027 |
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Inclusion Criteria: PET images available retrospectively
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Patients undergone allogeneic stemcell transplantation
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ksenia Boriskina | Recruiting | Stockholm | 14186 | Sweden |
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| ID | Term |
|---|---|
| D005221 | Fatigue |
| D006086 | Graft vs Host Disease |
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007154 | Immune System Diseases |
| D003072 | Cognition Disorders |
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| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |