'Propolis Versus Chlorhexidine Gluconate on Wound Healing After Third Molar Surgery: a Randomized Controlled Trial'

Clinical Evaluation Of The Effects Of Propolis Gargle On Wound Healing After Impacted Third Molar Surgery

The goal of this study is to examine the effects of propolis gargle on wound healing following third molar surgery and to compare it with chlorhexidine gluconate. The main question it aims to answer is:

Is propolis-containing gargle safe and effective alternative to chlorhexidine gluconate following impacted third molar surgery? Does propolis demonstrate comparable outcomes in pain control and mouth opening ?

This prospective, randomized clinical study included 52 healthy patients (ASA I) who underwent impacted mandibular third molar surgery. Patients were randomly allocated into two groups: one group used 0.12% chlorhexidine gluconate gargle, while the other used a 3% propolis-containing gargle. Gargles were applied twice daily for one minute from postoperative day 2 to day 7. Pain was evaluated using the visual analog scale (VAS), while edema, maximum mouth opening, wound healing, and postoperative complications were assessed preoperatively and on postoperative days 2 and 7. Statistical significance was set at p < 0.05.

Inclusion Criteria:

• Clinical diagnosis of the impacted teeth were classified as Class II level B mesioangular position
• Patients from a socioeconomic level who can actively use postoperative gargles

Exclusion Criteria:

• Individuals with third molars exhibiting acute infection
• smokers
• pregnant women