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This study retrospectively analyzed patients who underwent tracheal intubation under general anesthesia at the First Affiliated Hospital of Zhejiang University School of Medicine between October 1, 2015, and September 30, 2025, with a focus on issues related to postoperativelaryngopharyngeal complaints. Patients requiring otolaryngological consultation due to postoperative laryngopharyngeal complaints were identified via the case consultation system. Relevant patient data were collected through the Medison Anesthesia Information Management System and electronic medical record system, and telephone follow-up was conducted to assess patient prognosis. The primary outcome measures were the risk factors of postoperative hoarseness, while the secondary outcome measures included the incidence of postoperative hoarseness, the severity of vocal fold injury and its related risk factors. Additionally, the prognosis of patients and its related risk factors were evaluated. This study aims to reduce the incidence of perioperative laryngopharyngeal injury and provide a reference for the optimization of perioperative anesthetic regimens.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| hoarseness | We collected perioperative clinical data from the cohort, analyzed the associated risk factors for the occurrence of relevant symptoms, and investigated the prognosis. |
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| Measure | Description | Time Frame |
|---|---|---|
| Postoperative hoarseness | The patients underwent general anesthesia with tracheal intubation and required otolaryngological consultation for hoarseness between October 1, 2015, and September 30, 2025.Hoarseness is characterized by alterations in voice quality, pitch (how high or low the voice is), volume (loudness), or vocal effort that impair effective communication, as judged by a healthcare provider, and may adversely affect quality of life. | Perioperative,up to150 days |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of Hoarseness | (Number of patients with postoperative hoarseness） / (Total number of patients undergoing general anesthesia tracheal intubation) × 100% | Perioperative,up to150 days |
| the severity of hoarseness |
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Inclusion Criteria:
Exclusion Criteria:
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Patients who underwent endotracheal intubation under general anesthesia at the First Affiliated Hospital of Zhejiang University between October 1, 2015, and September 30, 2025
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Diansan Su | Contact | +8618616514088 | diansansu@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Diansan Su | Zhejiang University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| he First Affiliated Hospital, Zhejiang University School of Medicine | Completed | Hangzhou | Zhejiang | 310000 | China | |
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| ID | Term |
|---|---|
| D013274 | Stomach Neoplasms |
| D006528 | Carcinoma, Hepatocellular |
| D008175 | Lung Neoplasms |
| D010190 | Pancreatic Neoplasms |
| D018281 | Cholangiocarcinoma |
| D013964 | Thyroid Neoplasms |
| D006685 | Hoarseness |
| ID | Term |
|---|---|
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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Hoarseness was assessed as follows: 0 = none (no hoarseness), 1 = noticed by patient, 2 = obvious to observer, 3 = aphonia.
| Perioperative,up to150 days |
| Postoperative Vocal Fold Injury | Based on patients' hoarseness symptoms and laryngoscopic findings, an otolaryngologist conducted clinical assessment and grading, classifying vocal fold injury into four levels. The classification criteria were: Grade 0 (Normal): Non-hoarsenes; Grade 1 (Mild): hoarseness with negative laryngoscopic findings or vocal fold closure gap; Grade 2 (Moderate): hoarseness with vocal fold mobility impairment; Grade 3 (Severe): hoarseness with vocal cord paralysis or fixation. | Perioperative,up to150 days |
| Incidence of Arytenoid Dislocation | (Number of patients with postoperative arytenoid dislocation)/ (Total number of patients undergoing general anesthesia tracheal intubation) × 100% | Perioperative,up to150 days |
| The First Affiliated Hospital, Zhejiang University School of Medicine |
| Recruiting |
| Hangzhou |
| Zhejiang |
| 310000 |
| China |
| D004066 |
| Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D013272 | Stomach Diseases |
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D008113 | Liver Neoplasms |
| D008107 | Liver Diseases |
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D004701 | Endocrine Gland Neoplasms |
| D010182 | Pancreatic Diseases |
| D004700 | Endocrine System Diseases |
| D006258 | Head and Neck Neoplasms |
| D013959 | Thyroid Diseases |
| D014832 | Voice Disorders |
| D007818 | Laryngeal Diseases |
| D012120 | Respiration Disorders |
| D010038 | Otorhinolaryngologic Diseases |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012818 | Signs and Symptoms, Respiratory |