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Bedside colonoscopy 24-36 hours after successful CPR
According to previous observations, many patients after CPR develop acute non-occlusive mesenteric ischemia. However, due to the lack of established screening strategies, the number of unreported cases may be high. Routine colonoscopy at 24-36 hours after CPR may be a safe, easy and cost-effective strategy for early detection of severe mesenteric ischemia and transfer to surgical treatment. However, this strategy has not been formally evaluated in larger prospective cohorts. In our center, we perform routine colonoscopy at 24 to 36 hours after cardiac arrest in all patients who receive extracorporeal CPR (ECPR), i.e., in all patients with prolonged cardiac arrest refractory to conventional CPR measures who therefore receive venoarterial extracorporeal membrane oxygenation (VA ECMO) for cardiocirculatory support. In these patients, colonoscopy screening was feasible and safe, and our data suggest clinical benefit.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| early colonoscopy after successful CPR | Other | bedside colonoscopy 24-36 hours after successful CPR |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| colonoscopy | Procedure | bedside colonoscopy without bowel cleansing early (24-36h) after successful CPR |
|
| Measure | Description | Time Frame |
|---|---|---|
| Detection of colon ischemia | Detection of colon ischemia within 30 days after return of spontaneous circulation | from baseline (0 hours) until day 30 |
| Measure | Description | Time Frame |
|---|---|---|
| in-hospital mortality | in-hospital mortality | from baseline (0 hours) until hospital discharge |
| abdominal surgery ((hemi-)colectomy) | number of patients requiring/receiving abdominal surgery ((hemi-)colectomy) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Alexander Supady, MD, MPH | Contact | +49-761-270-34010 | alexander.supady@uniklinik-freiburg.de |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical Center - University of Freiburg | Freiburg im Breisgau | 79106 | Germany |
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| ID | Term |
|---|---|
| D006323 | Heart Arrest |
| D065666 | Mesenteric Ischemia |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D007410 | Intestinal Diseases |
| D005767 | Gastrointestinal Diseases |
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| ID | Term |
|---|---|
| D003113 | Colonoscopy |
| ID | Term |
|---|---|
| D016099 | Endoscopy, Gastrointestinal |
| D016145 | Endoscopy, Digestive System |
| D003938 | Diagnostic Techniques, Digestive System |
| D019937 | Diagnostic Techniques and Procedures |
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Prospective epidemiological incidence study
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| from baseline (0 hours) until hospital discharge |
| functional outcome | Cerebral Performance Category (CPC) | day 30, day 60 and day 90 |
| Liver function | Liver function parameters: Quick/INR, AST, ALT, AP, g-GT | within 0-72 hours after CPR |
| renal function | Renal function parameters: creatinine, BUN | within 0-72 hours after CPR |
| Urine output | Urine output (ml) | within 0-72 hours after CPR |
| Renal replacement therapy | Implementation of renal replacement therapy within 30 days after return of spontaneous circulation | from baseline (day 0) until day 30 |
| Serum lactate | Serum lactate | within 0-72 hours after CPR |
| SOFA score | SOFA | at 0 hours, 24 hours, 48 hours, 72 hours after CPR |
| SAPS II score | SAPS II | at 0 hours, 24 hours, 48 hours, 72 hours after CPR |
| D004066 |
| Digestive System Diseases |
| D010532 | Peritoneal Diseases |
| D014652 | Vascular Diseases |
| D003933 | Diagnosis |
| D004724 | Endoscopy |
| D003949 | Diagnostic Techniques, Surgical |
| D013505 | Digestive System Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D019060 | Minimally Invasive Surgical Procedures |