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The goal of this retrospective clinical trial is to find out association antiplatelet and anticoagulant therapy with perioperative complications in non-cardiac vascular surgery in patients . The main questions it aims to answer are:
Does the use of antiplatelet agents and anticoagulants affect the development of complications in the perioperative period during operations on the main arteries? Does discontinuing antiplatelet and anticoagulant medications affect the development of perioperative complications in major artery surgeries?? Researchers will compare with patients who didn't use antiplatelets and anticoagulant drugs to see ift he incidence of complications comparable?
This is a retrospective study based on the analysis of medical records (case histories).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Patients who did not take antiplatelet agents and anticoagulants | ||
| Antiplatelet and anticoagulants | Patients who use antiplatelet agents and anticoagulants until the operation day |
| |
| Discontinuation of antiplatelet and anticoagulants | Patients who discontinuate antiplatelet agents and anticoagulants until the operation day |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Aspirin | Drug | Patients who take aspirin until the operation day |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Bleeding | Case of bleeding or haematoma development | First 24 hours after operation |
| Measure | Description | Time Frame |
|---|---|---|
| Trombosis | First 24 hours after operation |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with surgical treatment of atherosclerotic lesions of the main arteries.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| NRCS Petrovsky | Moscow | 119991 | Russia |
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| Clopidogrel |
| Drug |
Patients who take clopidogrel until the operation day |
|
| Ticagrelor | Drug | Patients who take ticagrelor until the operation day |
|
| Dabigatran | Drug | Patients who take dabigatran until the operation day |
|
| Rivaroxaban | Drug | Patients who take rivaroxaban until the operation day |
|
| Apixaban | Drug | Patients who take apixaban until the operation day |
|
| Warfarin | Drug | Patients who take warfarin until the operation day |
|
| aspirin + clopidogrel | Drug | Patients who take aspirin and clopidogrel until the operation day |
|
| Aspirin + Ticagrelor | Drug | Patients who take aspirin and ticagrelor until the operation day |
|
| Aspirin + Apixaban | Drug | Patients who take aspirin and apixaban until the operation day |
|
| Aspirin + rivaroxaban | Drug | Patients who take aspirin and rivaroxaban until the operation day |
|
| Clopidogrel + Apixaban | Drug | Patients who take clopidogrel and apixaban until the operation day |
|
| Clopidogrel + Rivaroxaban | Drug | Patients who take clopidogrel and rivaroxaban until the operation day |
|
| ID | Term |
|---|---|
| D013927 | Thrombosis |
| D006470 | Hemorrhage |
| ID | Term |
|---|---|
| D016769 | Embolism and Thrombosis |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D001241 | Aspirin |
| D000077144 | Clopidogrel |
| D000077486 | Ticagrelor |
| D000069604 | Dabigatran |
| D000069552 | Rivaroxaban |
| C522181 | apixaban |
| D014859 | Warfarin |
| ID | Term |
|---|---|
| D012459 | Salicylates |
| D062385 | Hydroxybenzoates |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D013988 | Ticlopidine |
| D058924 | Thienopyridines |
| D013876 | Thiophenes |
| D013457 | Sulfur Compounds |
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D000241 | Adenosine |
| D011684 | Purine Nucleosides |
| D011687 | Purines |
| D009705 | Nucleosides |
| D009706 | Nucleic Acids, Nucleotides, and Nucleosides |
| D012263 | Ribonucleosides |
| D001562 | Benzimidazoles |
| D009025 | Morpholines |
| D010078 | Oxazines |
| D015110 | 4-Hydroxycoumarins |
| D003374 | Coumarins |
| D001578 | Benzopyrans |
| D011714 | Pyrans |
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