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Background:
Videolaryngoscopy has improved glottic visualization and facilitated tracheal intubation. However, difficulties-including failed intubation-still occur. At present, no prospectively derived classification system exists to assess the difficulty of videolaryngoscopic (VL) intubation across both normal and anticipated difficult airways. Additionally, current glottic view grading systems, designed for direct laryngoscopy, may not adequately capture the specific challenges of VL intubation.
Objectives:
This study aims to:
Background:
Videolaryngoscopy has improved glottic visualization and facilitated tracheal intubation. However, difficulties-including failed intubation-still occur. At present, no prospectively derived classification system exists to assess the difficulty of videolaryngoscopic (VL) intubation across both normal and anticipated difficult airways. Additionally, current glottic view grading systems, designed for direct laryngoscopy, may not adequately capture the specific challenges of VL intubation.
Objectives:
This study aims to:
Methods:
A prospective cohort of 4,977 patients will be enrolled. Patient and intubation related variables-including VL findings, airway features, clinical parameters, device, and procedural details-will be analyzed. Binary logistic regression will be employed to build the initial predictive model. In parallel, machine learning techniques (Random Forest, Support Vector Machine, XGBoost, LightGBM, etc.) will be applied to evaluate predictive performance. Comparative analysis will be conducted between the machine learning models and the logistic regression baseline.
Expected Impact:
The development of a robust predictive tool and an associated VL-specific glottic view score could enhance clinical decision making, particularly in identifying patients at risk of difficult or failed VL intubation. This may support early consideration of awake tracheal intubation, and use of standardized terminology and reduce complications associated with difficult airway management
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| Measure | Description | Time Frame |
|---|---|---|
| Failed first intubation attempt | Failed to intubate at firtst attempt | 2 minutes after anesthesia induction |
| Difficult intubation | Failed to intubate at 1-2 attempts and/or intubation duration longer than 120 second | 2 minutes after anesthesia induction |
| Failed intubation | Not able to intubate the patient | 2 minutes after anesthesia induction |
| Intubation duration | Time elapsed from entring the blade between the teeth to detecting an entidal carbondioxide trace | 2 minutes after anesthesia induction |
| Glottic view description | Vocal cords are fully visible Vocal cords are partially separately Vocal cords are not visible Cords are adducted Epiglottis is visible Epiglottis is large Epiglottis is small Epiglottis is edematous Epiglottis mass is present Arytenoids are visible Arytenoid luxation or subluxation Arytenoid edema Valecula problem (edema, Coffee grounds, etc., unable to insert a blade) Aryepiglottic plica pathology (edema, Coffee grounds scar) Laryngeal structures should be formed Glottic stenosis Laryngospasm | 2 minutes after anesthesia induction |
| Measure | Description | Time Frame |
|---|---|---|
| Percentil of glottic opening score | the percentage of glottic opening seen, defined by the linear span from the anterior commissure to the inter-arytenoid notch | 2 minutes after anesthesia induction |
| Cormack lehanne score |
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Inclusion Criteria:
Exclusion Criteria:
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Adults, both with normal or predicted difficult airways, undergoing orotracheal intubation with a videolarygoscope, for a case mix of surgeries
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dilek Yazıcıoğlu Ünal, Professor | Contact | +90 5336957855 | dilekunalmd@gmail.com | |
| Emel Gündüz, assoc. | Contact | +905444341719 | dregunduz@hotmail.com, |
| Name | Affiliation | Role |
|---|---|---|
| Dilek Yazıcıoğlu Ünal, professor | Ankara Etlik City Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Etlik City Hospital | Ankara | 06170 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38093485 | Background | Xia M, Jin C, Zheng Y, Wang J, Zhao M, Cao S, Xu T, Pei B, Irwin MG, Lin Z, Jiang H. Deep learning-based facial analysis for predicting difficult videolaryngoscopy: a feasibility study. Anaesthesia. 2024 Apr;79(4):399-409. doi: 10.1111/anae.16194. Epub 2023 Dec 13. | |
| 28337769 | Background | O'Loughlin EJ, Swann AD, English JD, Ramadas R. Accuracy, intra- and inter-rater reliability of three scoring systems for the glottic view at videolaryngoscopy. Anaesthesia. 2017 Jul;72(7):835-839. doi: 10.1111/anae.13837. Epub 2017 Mar 24. |
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grade 1 being a full view of the glottis, grade 2 being a partial view, grade 3 being only a view of the epiglottis, and grade 4 being an absent view of the glottis and epiglottis
| 2 minutes after anesthesia induction |
| Akdeniz University Medical Faculty | Antalya | Turkey (Türkiye) |