This is a single-center, randomized, exploratory clinical trial investigating whether intermittent enteral feeding improves outcomes compared to continuous feeding in patients with severe stroke. The study will enroll 60 patients to evaluate the impact on 90-day all-cause mortality, neurological function, nutritional status, and safety. It will also explore underlying mechanisms through analysis of metabolic profiles, circadian gene expression, and gut microbiota.

Inclusion Criteria:

1. Age ≥18 years old
2. It was definitely diagnosed as acute stroke by clinical imaging.
3. Enteral nutrition program can be started within 72 hours of onset.
4. Baseline GCS≤12 or NIHSS≥11
5. There is nutritional risk (NRS 2002≥3), Wadian drinking water test≥ 3 or there is consciousnessdisorder,it is estimated that you need to receive nutritional support treatment for ≥7 days
6. Obtain informed consent

Exclusion Criteria:

1. Before joining the group, he had received total parenteral nutrition treatment.
2. There are contraindications to enteral nutrition.
3. Unstable vital signs
4. Dementia or severe disability before onset (mRS≥3)
5. There are concomitant diseases that will interfere with outcome evaluation and/or follow-up.
6. Participating in other interventional clinical trials.
7. Other circumstances in which the study cannot be completed.