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Alzheimer's disease is the most common memory loss disease among the elderly. This disease affects the patient's memory, language, attention, and behavioral abilities. Current research has found that in the early stages of the disease, synaptic connections between brain nerve cells become abnormal, but the specific cause is still unclear. Investigators' previous research discovered that in the brains of diseased mice, certain special substances (the miR 342 5p/AnkG-mediated pathway) might be related to this abnormality, and these substances can be detected in both blood and cerebrospinal fluid. Therefore, investigators want to further explore the specific mechanisms of abnormal nerve cell connections, seek biomarkers for early detection of the disease, and provide new ideas for early diagnosis in the future.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AD Group | Experimental | Alzheimer's disease patients, collect peripheral blood, and if the patient agrees, also collect cerebrospinal fluid. |
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| Healthy control group | Other | Healthy control, collect peripheral blood, and if the patient agrees, also collect cerebrospinal fluid. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Collect peripheral blood, and if the patient consents, also collect cerebrospinal fluid. | Other | Collect peripheral blood, and if the patient consents, also collect cerebrospinal fluid. |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between miR-342-5p/AnkG Pathway and Synaptic Proteins | Quantitative Reverse Transcription-Polymerase Chain Reaction (QT-PCR) detection of microRNA-342-5p (miR-342-5p), Cytometric Bead Array (CBA) method detection of Ankyrin-G (AnkG), and Electrochemiluminescence (ECL) technology detection of neurogranin. Then analyze the correlation between miR-342-5p/AnkG and the synaptic protein neurogranin | Within 12 weeks after enrollment |
| Measure | Description | Time Frame |
|---|---|---|
| The correlation between miR-342-5p/AnkG pathway and cognitive function and brain atrophy | miR-342-5p was detected by qRT-PCR, AnkG was measured by CBA method, cognitive function was evaluated using neuropsychological scales, and hippocampal atrophy was assessed by structural MRI.Then analyze the correlation between miR-342-5p/AnkG and cognitive function and hippocampal atrophy | Within 12 weeks after enrollment |
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Inclusion Criteria:
Inclusion criteria for AD group:
Inclusion criteria for control group:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xu-hua Xu | Contact | +8613705790560 | fupinglangying@zju.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Fourth Affiliated Hospital of Zhejiang University School of Medicine | Recruiting | Yiwu | Zhejiang | 322000 | China |
Share after the paper is published, on the platform determined by the journal.
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| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| D024801 |
| Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |