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ClinicalTrials.gov ID

NCT07352696

Lead Sponsor

Vastra Gotaland RegionOTHER_GOV

Overall Status

Not yet recruiting

Study Type

Interventional

Phase

Not Applicable

Enrollment

88Estimated

Last Update Posted

Jan 22, 2026Actual

Start Date

Feb 2, 2026Estimated

Primary Completion Date

Dec 2027Estimated

Completion Date

Dec 2028Estimated

Official Title

Effects of Combined High-Intensity Aerobic Training and Resistance Training on Cardiovascular and Metabolic Health in Psoriatic Arthritis

Brief Summary

The goal of this randomised controlled trial is to evaluate the effects of a 12-week intervention comprising high-intensity interval aerobic training and strength training on cardiovascular function, metabolic health profile and inflammation in patients with Psoriatic arthritis. A secondary goal is to assess the intervention´s impact on physical fitness, pain, fatigue, and health-related quality of life, and to explore long-term maintenance of exercise following completion of the intervention. We hypothesize that 12 weeks of combined high-intensity interval aerobic training and strength training will improve cardiometabolic health, inflammation, and enhance physical fitness, fatigue, pain and quality of life in Psoriatic arthritis.

• Psoriatic Arthritis

• Exercise program

Ages Eligible for Study

Adult (18-64)Older Adult (65+)

Sexes Eligible for Study

All

Accepts Healthy Volunteers

No

Eligibility Criteria

Inclusion Criteria:

• Psoriatic arthritis disease according to the CASPAR (Classification Criteria for Psoriatic Arthritis) criteria
• Age range 18-65 years
• Stable medication on anti- rheumatic drugs for >3 months prior to inclusion and throughout the first 3 months of the study

Exclusion Criteria:

• Cardiovascular disease
• Severe hypertension
• Diabetes type I
• Chronic obstructive pulmonary disease or other severe pulmonary diseases
• Arthroplasty of large joints, lower extremities
• Severe functional impairment precluding participation in high-intensity aerobic exercise
• Inability to perform a cardiopulmonary exercise testing (CPET)
• Pregnancy
• BMI ≥35 kg/m²
• Ongoing or planned initiation (within 3 months) of structured weight reduction therapy, pharmacological obesity treatment, or bariatric bypass surgery
• Already participating in regular exercise at high intensity (BORG ≥15) for >1 hour/ week during the past 6 months
• Inability to understand and read Swedish

Primary Purpose

Treatment

Allocation

Randomized

Interventional Model

Parallel Assignment

Masking

Double

Lead Sponsor

Vastra Gotaland RegionOTHER_GOV

daniel.glinatsi@vgregion.se