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The goal of this observational study is to determine the prevalence of remission among adults with mild-to-moderate asthma, as well as the factors associated with remission in Thailand.
The main question the study aims to answer is:
What is the prevalence of remission among adults with severe asthma in Thailand? Participants will complete a questionnaire on asthma symptoms and undergo pulmonary function testing and a blood test once.
This study is a cross-sectional study. Thai patients aged 18 years or older with mild-to-moderate asthma are included in the study. Participants will complete two questionnaires about asthma control: the Global Initiative for Asthma (GINA) and the Asthma Control Test (ACT), and will perform spirometry, a fractional exhaled nitric oxide (FeNO) test, and blood eosinophil counts (BEC).
GINA and ACT are questionnaires used to assess the level of asthma control.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mild-to-moderate asthma | Patients aged 18 years or older with mild-to-moderate asthma. Mild asthma refers to asthma patients who experience symptoms <3 times per week, have preserved lung function (FEV₁ or PEF >80% of predicted), and whose symptoms can be adequately controlled with low-dose inhaled corticosteroids (low-dose ICS) alone, without the need for long-acting bronchodilators or other controller medications. Moderate asthma refers to asthma patients who have symptoms >4-5 days per week or experience nocturnal asthma symptoms >1 per week, and who require treatment with medium-dose inhaled corticosteroids (medium-dose ICS) or low-dose ICS in combination with a long-acting β₂-agonist (low-dose ICS/LABA) to achieve symptom control and prevent exacerbations. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Global Initiative for Asthma (GINA) and Asthma Control Test (ACT) questionnaires | Other | GINA and ACT are questionnaires used to assess the level of asthma control. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence rate of mild-to-moderate asthma remission | Prevalence rate of mild-to-moderate asthma remission (%) | An average of 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Asthma control in patients with mild-to-moderate asthma | Rate of patients with well-controlled asthma. Well-controlled asthma is defined as an Asthma Control Test (ACT) score of 20 or higher. | At baseline and at 12 months |
| Airway obstruction in patients with mild-to-moderate asthma |
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Inclusion Criteria:
Exclusion Criteria:
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Thai patients aged 18 years or older with mild-to-moderate asthma are included in the study
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Narongkorn Saiphoklang, MD | Contact | +6629269794 | M_narongkorn@hotmail.com | |
| Sirashat Hanvivattanakul, MD | Contact | +6629269701 | boss32_@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Narongkorn Saiphoklang, MD | Thammasat University Faculty of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Narongkorn Saiphoklang | Recruiting | Pathum Thani | Changwat Pathum Thani | 12120 | Thailand |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40091885 | Result | Ishizuka M, Sugimoto N, Kobayashi K, Takeshita Y, Imoto S, Koizumi Y, Togashi Y, Tanaka Y, Nagata M, Hattori S, Uehara Y, Suzuki Y, Toyota H, Ishii S, Nagase H. Clinical remission of mild-to-moderate asthma: Rates, contributing factors, and stability. J Allergy Clin Immunol Glob. 2025 Jan 30;4(2):100431. doi: 10.1016/j.jacig.2025.100431. eCollection 2025 May. | |
| 17360725 |
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IPD and documents will be available for sharing immediately after publication for a period of 2 years.
IPD and documents will be available for sharing immediately after publication for a period of 2 years.
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| Spirometry | Other | Spirometry is a tool used to assess pulmonary function. |
|
| Fractional exhaled nitric oxide (FeNO) test | Other | FeNO is a tool used to assess eosinophilic airway inflammation and asthma remission. |
|
| Blood eosinophil count (BEC) | Other | BEC is a tool used to assess eosinophilic inflammation and asthma remission. |
|
Airway obstruction is assessed using FEV1/FVC ratio on spirometry. |
| At baseline and at 12 months |
| Severity of aiway obstruction in patients with mild-to-moderate asthma | The severity of aiway obstruction is assessed using FEV1 % predicted on spirometry. | At baseline and at 12 months |
| Eosinophil airway inflammation in patients with mild-to-moderate asthma | Eosinophil airway inflammation is assessed using blood eosinophil count (cells/µL). | At baseline and at 12 months |
| Type 2 airway inflammation in patients with mild-to-moderate asthma | Type 2 airway inflammation is assessed using fractional exhaled nitric oxide (FeNO, ppb). | At baseline and at 12 months |
| Faculty of Medicine, Thammasat University | Recruiting | Pathum Thani | 12120 | Thailand |
|
| Holm M, Omenaas E, Gislason T, Svanes C, Jogi R, Norrman E, Janson C, Toren K; RHINE Study Group. Remission of asthma: a prospective longitudinal study from northern Europe (RHINE study). Eur Respir J. 2007 Jul;30(1):62-5. doi: 10.1183/09031936.00121705. Epub 2007 Mar 14. |
| 33220516 | Result | Tupper OD, Hakansson KEJ, Ulrik CS. Remission and Changes in Severity Over 30 Years in an Adult Asthma Cohort. J Allergy Clin Immunol Pract. 2021 Apr;9(4):1595-1603.e5. doi: 10.1016/j.jaip.2020.11.013. Epub 2020 Nov 19. |
| 40652405 | Result | Chiewchalermsri C, Kanjanawasee D, Saiphoklang N, Chirakalwasan N, Sriprasart T, Senavonge A, Sanguanwong N, Kamalaporn H, Athipongarporn A, Hachai S, Boonsawat W, Brannan JD, Song WJ, Ruxrungtham K, Poachanukoon O. Asthma remission: A path to cure? Asian Pac J Allergy Immunol. 2025 Jun;43(2):135-150. doi: 10.12932/AP-240525-2082. |
| ID | Term |
|---|---|
| D001249 | Asthma |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012130 | Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
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| ID | Term |
|---|---|
| D011795 | Surveys and Questionnaires |
| ID | Term |
|---|---|
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
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