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The goal of this observational study is to learn whether noninvasive real-time arterial waveform monitoring can be used to assess cardiovascular diseases in adults. The main question it aims to answer is:
Can photoacoustic imaging accurately capture arterial waveforms from patients' fingers? Can features extracted from the arterial waveforms reflect the type and severity of cardiovascular diseases? Participants will be asked to place their fingers into the imaging device, where their finger arterial pulse information will be noninvasively recorded.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy Subjects | Healthy adult volunteers with no known cardiovascular disease will undergo noninvasive arterial waveform acquisition using the photoacoustic imaging device. No intervention is applied; data collection provides baseline waveform features for comparison with AR and AS patients. | ||
| Aortic Regurgitation (AR) Patients | Participants diagnosed with aortic regurgitation (AR) will undergo noninvasive arterial waveform acquisition using a photoacoustic imaging device. No intervention is applied; data collection focuses on capturing finger arterial pulse waveforms to assess features associated with AR. | ||
| Aortic Stenosis (AS) Patients | Participants diagnosed with aortic stenosis (AS) will undergo noninvasive arterial waveform acquisition using the same photoacoustic imaging device. No intervention is applied; data collection focuses on capturing finger arterial pulse waveforms to assess features associated with AS. |
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| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of the state of aortic regurgitation and aortic stenosis by photoacoustic tomography | To determine the feasibility of using photoacoustic tomography to differentiate aortic regurgitation and aortic stenosis based on arterial waveform measurements. | At enrollment (single time point) |
| Measure | Description | Time Frame |
|---|---|---|
| Rise time of photoaocustic arterial waveform | To determine the systolic upstroke rise time of arterial waveforms using photoacoustic tomography | At enrollment (single time point) |
| Decay time of photoaocustic arterial waveform |
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Inclusion Criteria:
Exclusion Criteria:
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Participants will be recruited from adult patients attending the cardiology department at the First Affiliated Hospital of University of Science and Technology of China, including individuals diagnosed with aortic regurgitation (AR) or aortic stenosis (AS), as well as healthy adult volunteers without known cardiovascular disease. Recruitment will focus on adults aged 18-80 years who are able to comply with finger arterial waveform measurement procedures.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| the First Affiliated Hospital of University of Science and Technology of China | Recruiting | Hefei | Anhui | 230026 | China |
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To determine the diastolic decay time of arterial waveforms using photoacoustic tomography
| At enrollment (single time point) |
| Dicrotic notch time of photoaocustic arterial waveform | To determine the dicrotic notch time of arterial waveforms using photoacoustic tomography | At enrollment (single time point) |