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Obesity is a major global public health concern, and bariatric surgery is recognized as the most effective treatment for achieving sustained weight loss and improving obesity-related comorbidities. Sleeve gastrectomy (SG) is one of the most commonly performed bariatric procedures; however, long-term outcomes vary considerably among individuals. While some patients maintain satisfactory weight loss, others experience suboptimal weight loss or weight regain several years after surgery. Evidence suggests that long-term weight trajectories after SG may be influenced by metabolic changes, dietary habits, and lifestyle factors, highlighting the need for extended follow-up studies.
This observational cohort study aims to evaluate the long-term outcomes of individuals who underwent sleeve gastrectomy approximately 8 years ago. Anthropometric measurements, biochemical parameters, and nutritional status will be reassessed at an 8-year follow-up visit and compared with data obtained during the preoperative period and at postoperative 6 months. By examining within-subject changes over time, this study seeks to provide insight into the long-term sustainability of weight loss after sleeve gastrectomy and to identify metabolic and nutritional factors associated with long-term outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sleeve Gastrectomy Long-Term Follow-up Cohort | This cohort includes adults who underwent sleeve gastrectomy between 2016 and 2017 and were re-evaluated approximately 8 years after surgery. Participants are followed observationally, with anthropometric measurements, biochemical parameters, and nutritional status assessed preoperatively, at postoperative 6 months, and at long-term (8-year) follow-up. No intervention is assigned as part of the study protocol; all surgical procedures were performed as part of routine clinical care. |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in Fat Mass | Changes in fat mass measured using multi-frequency bioelectrical impedance analysis (BIA). | Preoperative, postoperative 6 months, and postoperative 8 years |
| Change in Body Weight | Body weight measured using a calibrated digital scale with participants wearing light clothing and no shoes. | Preoperative, postoperative 6 months, and postoperative 8 years |
| Change in Body Mass Index (BMI) | BMI calculated as weight in kilograms divided by height in meters squared (kg/m²), measured using a wall-mounted stadiometer. | Preoperative, postoperative 6 months, and postoperative 8 years |
| Change in Waist Circumference | Waist circumference measured in centimeters at the midpoint between the subcostal margin and the iliac crest with participants standing upright. | Preoperative, postoperative 6 months, and postoperative 8 years |
| Change in Hip Circumference | Hip circumference measured in centimeters at the level of maximum gluteal protrusion. | Preoperative, postoperative 6 months, and postoperative 8 years |
| Percent Total Weight Loss (TWL%) | Calculated as [(preoperative weight - postoperative weight) / preoperative weight] × 100. | Postoperative 6 months and postoperative 8 years |
| Percent Excess Weight Loss (EWL%) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Fasting Plasma Glucose | Fasting plasma glucose measured after at least 8 hours of fasting using venous blood samples. | Preoperative, postoperative 6 months, and postoperative 8 years |
| Change in Fasting Insulin Levels |
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Inclusion Criteria:
Exclusion Criteria:
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The study population includes adults aged 18-65 years who underwent sleeve gastrectomy approximately eight years prior to enrollment and completed standard postoperative follow-up. Participants had available preoperative and 6-month postoperative anthropometric, biochemical, and nutritional data and were re-evaluated at 8 years after surgery to assess long-term outcomes.
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| Name | Affiliation | Role |
|---|---|---|
| Seher Şen | Mudanya University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mudanya Univesity | Bursa | Mudanya | Turkey (Türkiye) |
Individual participant data will not be shared due to the need to protect patient privacy and confidentiality. T
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D050177 | Overweight |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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Calculated as [(preoperative weight - postoperative weight) / (preoperative weight - ideal body weight)] × 100, where ideal body weight corresponds to a BMI of 25 kg/m².
| Postoperative 6 months and postoperative 8 years |
| Change in Body Fat Percentage | Changes in body fat percentage measured using multi-frequency bioelectrical impedance analysis (BIA). | Preoperative baseline, postoperative 6 months, and postoperative 8 years |
| Change in Skeletal Muscle Mass | Changes in skeletal muscle mass measured using multi-frequency bioelectrical impedance analysis (BIA). | Preoperative baseline, postoperative 6 months, and postoperative 8 years |
Fasting insulin levels measured from venous blood samples obtained after at least 8 hours of fasting.
| Preoperative, postoperative 6 months, and postoperative 8 years |
| Change in Glycated Hemoglobin (HbA1c) | HbA1c levels measured to assess long-term glycemic control. | Preoperative, postoperative 6 months, and postoperative 8 years |
| Change in Lipid Profile Parameters | Serum lipid parameters including total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides measured after an overnight fast. | Preoperative, postoperative 6 months, and postoperative 8 years |
| Change in Liver Enzyme Levels | Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels measured from fasting blood samples. | Preoperative, postoperative 6 months, and postoperative 8 years |
| Change in Renal and Metabolic Biomarkers | Serum urea and uric acid levels measured to assess renal and metabolic function. | Preoperative, postoperative 6 months, and postoperative 8 years |
| Change in Serum Albumin | Changes in serum albumin levels measured from venous blood samples. | Preoperative, postoperative 6 months, and postoperative 8 years |
| Change in Micronutrient Levels | Serum levels of vitamin B12, folic acid, magnesium, total calcium, sodium, and potassium measured to assess micronutrient status. | Preoperative, postoperative 6 months, and postoperative 8 years |
| Change in Physical Activity Level | Physical activity levels assessed using the International Physical Activity Questionnaire (IPAQ). | Preoperative, postoperative 6 months, and postoperative 8 years |
| Change in Fat-Free Mass | Changes in fat-free mass measured using multi-frequency bioelectrical impedance analysis (BIA). | Preoperative baseline, postoperative 6 months, and postoperative 8 years |
| Change in Total Protein | Changes in total serum protein levels measured from venous blood samples. | Preoperative baseline, postoperative 6 months, and postoperative 8 years |
| Change in Hemoglobin | Changes in hemoglobin levels measured from venous blood samples. | Preoperative baseline, postoperative 6 months, and postoperative 8 years |
| Change in Hematocrit | Changes in hematocrit levels measured from venous blood samples. | Preoperative baseline, postoperative 6 months, and postoperative 8 years |
| Change in Serum Ferritin | Changes in serum ferritin levels measured from venous blood samples. | Preoperative baseline, postoperative 6 months, and postoperative 8 years |
| Change in Serum Iron | Changes in serum iron levels measured from venous blood samples. | Preoperative baseline, postoperative 6 months, and postoperative 8 years |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |