Diuretic Effect of Aminophylline and Furosemide in Adult... | NCT07348510

Studies
Diuretic Effect of Aminophylline and Furosemide in Adult Patients Undergoing Cardiac Surgical Procedures

NCT07348510

Sponsor

Cairo University

Status

Recruiting

Last Update Posted

Jan 21, 2026Actual

Enrollment

106Estimated

Phase

Not Applicable

Conditions

Diuretic Effect
Aminophylline
Furosemide
Cardiac Surgical Procedures

Interventions

Aminophylline
Furosemide

Countries

Egypt

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

Jan 2026

Overall Recruitment Status or Expanded Access Status

Recruiting

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Jan 17, 2026Actual

Primary Completion Date

Jul 26, 2026Estimated

Completion Date

Jul 26, 2026Estimated

First Submitted Date

Jan 7, 2026

First Submission Date that Met QC Criteria

Jan 15, 2026

First Posted Date

Jan 16, 2026Actual

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Jan 17, 2026

Last Update Posted Date

Jan 21, 2026Actual

Sponsor/Collaborators Module

Responsible Party, by Official Title

Ahmed Mohamed Hassan, Assistant Lecturer of Anesthesia, surgical ICU and Pain management, Cairo University, Cairo, Egypt, Cairo UniversityPrincipal Investigator

Lead Sponsor

Cairo UniversityOTHER

Collaborators

Not provided

Oversight Module

Has Data Monitoring Committee (DMC)

Not provided

Is FDA Regulated Drug

Is FDA Regulated Device

Is Unapproved Device

Not provided

Pediatric Postmarket Surveillance of a Device Product

Not provided

Product Exported from US

Not provided

FDAAA801 Violation

Not provided

Description Module

Brief Summary

This work aims to investigate the diuretic effect of Aminophylline in comparison to Furosemide in adult patients undergoing cardiac surgical procedures.

Detailed Description

Acute Kidney injury (AKI) is a serious and common complication after either adult or pediatric cardiac surgery.

The results of a recent meta-analysis suggested that loop diuretics (furosemide) may reduce postoperative creatinine clearance, whereas aldosterone agonists (spironolactone) increase the incidence of cardiac surgery-associated acute kidney injury (CSA-AKI). Diuretics are not recommended for the prevention of AKI, but loop diuretics may be used for the management of volume overload Aminophylline in cardiac surgery can reduce the frequency of AKI and could be used in the prevention of AKI as a safe and efficient modality in high-risk patients.

Design Module

Study Type

Interventional

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Not provided

Target Follow-Up Duration

Not provided

Phases

Not Applicable

Interventional Study Design

Allocation

Biospecimen

No data available

No data is available for this block.

Enrollment

106Estimated

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Aminophylline group (control group)	Active Comparator	Patients will receive Aminophylline.	Drug: Aminophylline
Furosemide group	Experimental	Patients will receive furosemide.	Drug: Furosemide

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Aminophylline	Drug	Patients will receive Aminophylline.	Aminophylline group (control group)

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Measurement of urine output	Urine output will be measured at two hours after cardiopulmonary bypass.	Two hours after cardiopulmonary bypass

Secondary Outcomes

Measure	Description	Time Frame
Measurement of urine output at completion of cardiopulmonary bypass	Urine output at completion of cardiopulmonary bypass (CPB) will be measured at 8 hours and 48 hours after CPB.	48 hours after cardiopulmonary bypass
Urea level

Other Outcomes

Not provided

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

Age from 18-65 years.
Both sexes.
All adult patients presenting for elective cardiac surgical procedures performed on cardiopulmonary bypass (Coronary artery bypass surgery, Cardiac valve repair and/or replacement, Repair of large septal defects, Repair and/or palliation of congenital heart defects, Transplantation, surgery of thoracic aneurysms.).
Body mass index (BMI) ranged between 20 and 40 kg/m2.

Exclusion Criteria:

Sensitivity or contraindication to Aminophylline or furosemide
Stage-5 chronic kidney disease (CKD) [Glomerular filtration rate (GFR) of less than 15 mL/min].
The presence of both factors (GFR less than 60 mL/min and albumin greater than 30 mg per gram of creatinine) along with abnormalities of kidney structure or function for greater than three months signifies chronic kidney disease.
Recipients of dialysis before surgery.
Recipients of solid-organ transplantation before surgery.
Emergency cardiac surgical procedures (e.g. left main coronary artery bypass graft, stuck valves, etc).
Patient refusal.

Accepts Healthy Volunteers

Sex

All

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

18 Years

Maximum Age

65 Years

Standard Ages

AdultOlder Adult

Study Population

Not provided

Sampling Method

Not provided

Name	Role	Phone	Extension	Email
Ahmed M Hassan, MSc	Contact	00201033752020		ahm33hassan@gmail.com

Facility	Status	City	State	ZIP	Country	Contacts
Cairo University	Recruiting	Cairo		12613	Egypt

IPD Sharing Statement Module

Plan to Share IPD

Yes

Description

The data will be available upon a reasonable request from the corresponding author after the end of study for one year.

Types

Study Protocol

Time Frame

After the end of study for one year.

Access Criteria

The data will be available upon a reasonable request from the corresponding author.

URL

Not provided

Intervention Browse Module

MeSH Terms

ID	Term
D000628	Aminophylline
D005665	Furosemide

Ancestor Terms

ID	Term
D005029	Ethylenediamines
D003959	Diamines
D011073	Polyamines
D000588	Amines
D009930

Browse Leaves

Not provided

Browse Branches

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