A Study Testing the Effects of Different THC Doses on Psychological and Biological Function

Acute Dose-Dependent Effects of Oral THC on Physiological and Subjective Responses in Healthy Cannabis-Experienced Adults

The goal of this clinical trial is to learn how a investigational medicinal product (THC) affects psychological and physical responses in healthy adults with prior cannabis use experience. The main questions it aims to answer are:

- How do different dose levels of the investigational medicinal product (THC) influence short-term subjective and physiological responses?

Researchers will compare three dose levels of the study drug to a placebo (a look-alike substance with no active ingredient) to see how responses vary across sessions.

Participants will:

• Attend four in-person study visits, each involving a single dose of either the study drug or placebo
• Complete questionnaires about their moment-to-moment experiences
• Have their heart rate, blood pressure, and other physical measures monitored
• Undergo serial blood sampling to measure circulating biomarkers

Inclusion Criteria:

• Adults aged 18-55
• No major medical or psychiatric conditions
• At least one previous, well-tolerated experience with cannabis
• Not currently pregnant or breastfeeding

Exclusion Criteria:

• Family history (first- or second-degree relatives) of bipolar disorder, psychosis, or schizophrenia
• Significant negative reaction to cannabis in the past or known allergy to cannabis products
• Currently using recreational drugs