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This study aims to understand how the volumes and speeds of intravenous injection of a recent type of contrast agent can be optimized in order to improve the information provided by medical images. To do this, five MRI scans lasting approximately 30 minutes will be performed on 10 healthy volunteers over a period of approximately 10 months. The images will then be analyzed by three radiologists who will view the images in different orders, without knowing which injection parameters were used. They will decide, based on their impressions but also on precise measurements in the images, which parameters produce the best images.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Injection protocol 1: gadopiclenol 2 mL/s | Experimental |
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| Injection protocol 2: gadopiclenol 1 mL/s | Experimental |
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| Injection protocol 3: gadopiclenol 0.5 mL/s | Experimental |
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| Injection protocol 4: gadopiclenol half dose | Experimental |
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| Injection protocol 5: gadoteric acid 1 mL/s | Active Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| contrast agent, Gadolinium | Drug | Each participant undergoes five abdominal MRI exams with distinct injection protocols in a random order with at least a 2-week interval between each exams. |
| Measure | Description | Time Frame |
|---|---|---|
| Qualitative evaluation of MRI images | The qualitative evaluation of the MRI images, as assessed by the median composite score of three five-items Likert scales (0 = non-diagnostic or unacceptable; 1 = poor; 2 = fair; 3 = good; 4 = excellent) across the rating of three experienced radiologists. The three Likert scales concern i) the border delineation of the vessel measured using slopes perpendicular to the vessel walls, ii) the internal homogeneity in the vessel, and iii) the visual degree of contrast enhancement. The composite score thus ranges from 0 to 12 for each reader and then the middle score (i.e., the median) between all three readers is taken for increased reliability. | October 2026 |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| HFR Hôpital fribourgeois | Fribourg | Canton of Fribourg | 1700 | Switzerland |
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| ID | Term |
|---|---|
| D003287 | Contrast Media |
| D005682 | Gadolinium |
| ID | Term |
|---|---|
| D064907 | Diagnostic Uses of Chemicals |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D020313 | Specialty Uses of Chemicals |
| D028581 | Lanthanoid Series Elements |
| D008674 | Metals, Rare Earth |
| D004602 | Elements |
| D007287 | Inorganic Chemicals |
| D008670 | Metals |
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