This project will compare the uptake of cervical cancer screening through ED HPV sampling among patients presenting to the ED.

This is a single-arm pilot trial with a prospectively enrolled sample. The participants who complete the screening survey and are determined to be adherent (n ~ 600) will be notified that they appear to be adherent with current screening guidelines, and their participation ends at this point. These participants will be considered screen failures for study purposes. Women and transgender/non-binary individuals with a cervix, aged 30-65, will be recruited from a high-volume urban ED. Follow-up will occur at 150 days to determine CC screening activity, perceived and concrete barriers to care, and participant experiences with the intervention. Electronic Health Record (EHR) review will be conducted to corroborate participants' reports of screening activities and assess completion of clinic-based testing and clinical endpoints.

Inclusion Criteria:

• Cisgender women and transgender/non-binary individuals with a cervix,
• Age 30 - 65 years, and demonstrating decisional capacity to consent to participate with no known exclusion criteria present.

Exclusion Criteria:

• Past hysterectomy with cervical removal
• Known infection with HIV (as screening recommendations for people with HIV differ from the general population)
• Inability to consent (e.g., lacking decisional capacity, intoxicated, or in distress)
• Current pregnancy or in the three months after giving birth
• Use of vaginal ovules, creams or washes, vaginal contraceptives or condoms within past 3 days
• Sexual intercourse or transvaginal ultrasound scans or gynecological examinations within past 2 days

No decision has been made to share individual participant data however there is no current plan to share on an individual basis.