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Comparison of Volume-Stable Collagen Matrix, Platelet-Rich Fibrin, and Subepithelial Connective Tissue Graft in the Treatment of Multiple Adjacent Gingival Recessions: A Parallel-Group, Randomized, Controlled Clinical Trial
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Volume Stable Collagen Matrix+Coronally Advanced Flap | Experimental | The pre-prepared Volume Stable Collagen Matrix will be moistened with saline solution (SF) and placed beneath a coronally positioned flap at the recipient site during periodontal surgery. |
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| Platelet-Rich Fibrin+Coronally Advanced Flap | Active Comparator | Autologous platelet-rich fibrin (PRF) will be prepared from the patient's venous blood according to a standardized protocol and placed beneath a coronally advanced flap at the recipient site during periodontal surgery to enhance soft tissue healing and regeneration. |
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| Subepithelial Connective Tissue Graft+Coronally Advanced Flap | Active Comparator | A subepithelial connective tissue graft harvested from the patient's palate and placed beneath a coronally positioned flap at the recipient site during periodontal surgery. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Volume-Stable Collagen Matrix | Biological | Volume-Stable Collagen Matrix |
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| Measure | Description | Time Frame |
|---|---|---|
| Percentage of Complete Root Coverage | Percentage of CRC will be calculated as: (number of teeth achieving complete root coverage) ÷ (total treated teeth)] × 100 | 12 Months |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of Mean Root Coverage | Percentage of root coverage will be calculated as: Percentage of root coverage: [(preoperative recession depth - postoperative recession depth) ÷ preoperative recession depth] × 100 | 12 months |
| Recession depth |
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Inclusion criteria were as follows:
Exclusion criteria included:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ankara Yıldırım Beyazit University | Ankara | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D005889 | Gingival Recession |
| ID | Term |
|---|---|
| D005882 | Gingival Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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A Parallel-Group, Randomized, Controlled Clinical Trial
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RD will be measured from the cemento-enamel junction (CEJ) to the gingival margin and reported in millimeters (mm).
| 12 month |
| Probing depth | Probing depth will be measured from the gingival margin to the base of the sulcus and reported in millimeters (mm). | 12 months |
| Clinical attachment level | Clinical attachment level will be measured from the cemento-enamel junction to the sulcus base and reported in millimeters (mm). | 12 months |
| Keratinized gingiva width | KGW will be measured from the mucogingival junction to the gingival margin and reported in millimeters (mm). | 12 months |
| Gingival Thickness | Gingival thickness (GT) will beevaluated at the mid-facial aspect, 2 mm apical to the gingival margin in the attached gingiva or alveolar mucosa, using a #15 endodontic spreader (Bahadır Diş, Istanbul, Turkey) with a rubber stopper under local anesthesia and reported in milimeters. | 12 months |
| Postoperative Pain assessed using a Visual Analog Scale (VAS) | Postoperative pain will be assessed using a visual analog scale (VAS). Patients were asked to record the highest perceived pain each day from the day of surgery through the 10th postoperative day (total of 11 days). | From the day of surgery through postoperative day 10 (11 days) |
| Dentin Hypersensitivity Score assessed using Air Stimulus (HSS) | Dentin hypersensitivity will be assessed using a 1-second air stimulus applied to the buccal surface of the treated tooth. Patients rated the perceived hypersensitivity on a numerical rating scale ranging from 0 (no hypersensitivity) to 10 (unbearable hypersensitivity). | Baseline, 6 months, and 12 months |
| Pink Esthetic Score (PES) self-assessment | Esthetic outcomes will be evaluated using the Pink Esthetic Score (PES). Patients self-assessed gingival contour, gingival color, and overall esthetic appearance using a numerical rating scale ranging from 0 (unpleasant) to 10 (excellent). | Baseline, 6 months, and 12 months |
| Postoperative Analgesic Consumption | Postoperative analgesic consumption will be assessed by recording the total number of analgesic tablets taken by patients from the day of surgery through the 10th postoperative day. | From the day of surgery through postoperative day 10 (11 days) |
| D055093 |
| Periodontal Atrophy |