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| ID | Type | Description | Link |
|---|---|---|---|
| Alexandria University | Other Identifier | alex main university hospital |
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Impact of Immunosuppressive Therapy for Sarcoidosis on Lymphoma Development
This is a prospective observational cohort study to be conducted in the Chest Diseases Department, Alexandria Main University Hospital. A total of 40 adult patients (≥16 years) with biopsy-proven sarcoidosis will be consecutively recruited between December 2024 and December 2025. All patients will be either newly starting or continuing immunosuppressive therapy for sarcoidosis. The treatment regimen-systemic corticosteroids, conventional steroid-sparing agents (methotrexate, azathioprine, or mycophenolate), or biologics (anti-TNF agents)-will be recorded but not altered by study design. Each patient will be followed prospectively for 12 months from enrollment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Inclusion criteria include adult patients (≥16 years) with histologically confirmed sarcoidosis, rec | This is a prospective observational cohort study to be conducted in the Chest Diseases Department, Alexandria Main University Hospital. A total of 40 adult patients (≥16 years) with biopsy-proven sarcoidosis will be consecutively recruited between December 2024 and December 2025. All patients will be either newly starting or continuing immunosuppressive therapy for sarcoidosis. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| lymph node biopsy | Procedure | sarcoidosis diagnosis by lymph node biopsy excisiona or bronchoscopic |
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| Measure | Description | Time Frame |
|---|---|---|
| The primary outcome will be incident, biopsy-proven lymphoma during the 12-month follow-up. | LYMPH NODE BIOPSY EITHER EXCISIONAL OR BRONCHOSCOPIC | 12 MONTHS |
| lymphoma development | lymph node biopsy excisional or bronchoscopic | 12 months |
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Inclusion Criteria:
Exclusion Criteria:Patients with a prior history of lymphoma or other active malignancy, HIV infection, or other primary immunodeficiency will be excluded.
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Prospective cohort
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| Name | Affiliation | Role |
|---|---|---|
| ahmed mahmoud fawzy, professor | Alexandria University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Alexandria main university hospital | Alexandria | Asafra | 11511 | Egypt |
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| Label | URL |
|---|---|
| pubmed | View source |
| national library of diseases | View source |
| ID | Type | URL | Comment |
|---|---|---|---|
| statistics | Statistical Analysis Plan | View IPD |
not allowed in our department
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| ID | Term |
|---|---|
| D017565 | Sarcoidosis, Pulmonary |
| D008223 | Lymphoma |
| D012507 | Sarcoidosis |
| ID | Term |
|---|---|
| D017563 | Lung Diseases, Interstitial |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D008232 | Lymphoproliferative Disorders |
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| ID | Term |
|---|---|
| D021701 | Sentinel Lymph Node Biopsy |
| ID | Term |
|---|---|
| D001706 | Biopsy |
| D003581 | Cytodiagnosis |
| D003584 | Cytological Techniques |
| D019411 | Clinical Laboratory Techniques |
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pending |
| D008206 | Lymphatic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D006968 | Hypersensitivity, Delayed |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D007160 | Immunoproliferative Disorders |
| D019937 |
| Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D013048 | Specimen Handling |
| D003949 | Diagnostic Techniques, Surgical |
| D013514 | Surgical Procedures, Operative |
| D008197 | Lymph Node Excision |
| D008919 | Investigative Techniques |