Gastrointestinal Symptoms and Tolerance in Infants Fed Goat or Cow's Milk-based Infant Formula

Effect of a Goat-milk Based Infant Formula on Gastrointestinal Symptoms and Tolerability in Healthy Term Infants: a Double-blind Randomized Controlled Trial

This randomized controlled double-blind study will compare the effect of a commercially available goat milk formula to a cow's milk formula on gastrointestinal symptoms and tolerance, and infections in infants.

Inclusion Criteria:

• Age between 14 days and 90 days.
• Healthy singleton term infants born between 37 weeks and 42 weeks of gestation.
• Infants who have received CMF for at least 7 consecutive days.
• Exclusive formula feeding.
• Cow's Milk-related Symptoms Score (CoMiSS®) value at baseline of ≥6 and <10.
• Parents' or caregivers, aged ≥18 years, willing to give informed consent and adhere to study protocol

Exclusion Criteria:

• Exclusively or partially feeding with human milk
• Introduced to solid food, supplementary feeding, use of pre- and/or probiotics as a supplement
• Congenital or recurrent chronic conditions and/or malabsorption that could interfere with study parameters.
• Diagnosed cow's milk allergy (CMA) or suspected to have CMA, soy allergy, fish allergy, egg allergy and/or lactose intolerance.
• Receiving medication (on own initiative or prescription) with regard to FGID (i.e. reflux medication)
• Sibling already participating in this study
• Participation in another clinical trial